BACKGROUND Secondary hyperparathyroidism (SHPT) is a severe complication for dialysis patients. Vitamin D receptor activators (VDRAs) are used to treat SHPT, but the comparative efficacy and safety between paricalcitol and other vitamin D receptor activators for management of SHPT in dialysis patients has been unproven. METHODS We searched PubMed, Embase, and the Cochrane Library for the time...

BACKGROUND Dermatan sulphate (DS) is a selective thrombin inhibitor with antithrombotic properties and low bleeding potential. In preliminary studies it was reported to be effective for preventing clot formation in the haemodialysis circuit. METHODS Ten patients on maintenance haemodialysis for chronic renal failure underwent three consecutive investigation phases. In phase 1 (individual dose...

The risks of both ischemic and hemorrhagic stroke are particularly high in dialysis patients of any age and outcomes are poor. It is therefore important to identify strategies that safely minimize stroke risk in this population. Observational studies have been unable to clarify the relative importance of traditional stroke risk factors such as blood pressure and cholesterol in those on dialysis...

BACKGROUND AND AIMS Hepatitis C virus (HCV) infection is a frequent complication among long-term dialysis patients. The aim of the present study was to evaluate the efficacy and side effects of pegylated interferon-α(2a) (PEG-IFN-α(2a)) treatment in hemodialysis patients. METHODS We retrospectively reviewed charts of 16 HCV-RNA-positive hemodialysis patients. RESULTS There were 11 male and ...

Objectives: Malnutrition is a common problem in chronic renal disease patients during pre-dialysis and dialysis, leading to increased cardiovascular diseases mortality. This study aimed evaluate the efficacy of supplemental protein supplementation on malnutrition peritoneal dialysis patients. Methods: Eighty-four stable adult included this study. In addition standard diets, oral nutritional pro...

Recent years, multiple studies regarding clinical efficacy and risks of Warfarin therapy in dialysis patients have been reported, and not a few reports conclude that clinical advantage of Warfarin is questionable in dialysis patients. Conversely, its hemorrhagic risk might be a little more serious in dialysis patients comparing to non-dialysis patients. Basically, it is assumed that long-term a...

introduction: peritoneal dialysis is an established form of renal replacement therapy used in many patients with end – stage renal disease . peritoneal dialysis has different complications this study was conducted in order to evaluate its complications and different survival probabilities of factors in shahid rahnemoon hospital . methods: in this retrospective, historical cohort study, reports ...

Chronic renal failure is characterized by an increased risk for cardiovascular morbidity and mortality, including acute myocardial infarction (AMI). AMI is associated with poor long-term survival in dialysis patients; the 2-year survival rate of 25% has remained unchanged over the past 2 decades. Although underuse of appropriate therapies likely contributes to adverse outcomes, recent data sugg...

OBJECTIVE Ferumoxytol has demonstrated superior efficacy compared with oral iron in treating iron deficiency anemia in chronic kidney disease (CKD) patients. However, an economic evaluation of ferumoxytol has not been conducted. The aim of this study was to analyze the cost-effectiveness of treating iron deficiency anemia in adult non-dialysis-dependent CKD patients with ferumoxytol as compared...