Department of Medicine, University of Toronto, Toronto, Ontario, Canada Evaluative Clinical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Division of General Internal Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Center for Leading Injury Prevention Practice Education & Rese...

Although inferior petrosal sinus sampling (IPSS) is useful in the evaluation of Cushing's syndrome, false negative cases have been described, and many patients presumed to have ectopic tumors based upon negative IPSS remain without a final diagnosis. These patients are often managed as if they have as yet undiscovered ectopic tumors. To test this assumption, we conducted a retrospective review ...

Fibrous dysplasia is a benign disorder in which the normal structure of the bone and marrow is replaced by fibrous tissue1,2. It was first described by Lichtenstein in 19383 and it represents 5 to 7% of all benign bone tumors4,5. This lesion type can involve a single bone or multiple bones, in one-fourth of the cases being localized at the head and neck level2. In patients with skull involvemen...

Diagnosis is the most difficult thing we do. We usually do it well, but we are not perfect. Diagnostic errors are important because they are common,1,2 and they harm patients and physicians.3,4 Until recently, physicians and hospitals have ignored diagnostic errors, partly because they are not like other kinds of medical errors. They are more difficult to define and detect, more difficult to pr...

OBJECTIVE To test the previously described misdiagnosis severity score (MSS) by comparing it with doctors' perceptions of the severity of diagnostic errors. METHODS 14 scenarios of diagnostic errors were described on a questionnaire. These were given to 12 accident and emergency (A&E) consultants who were asked to indicate their assessment of the severity of the errors on a scale of 1 to 10. ...