The flowers of Malva sylvestris Linn. (Malvaceae) and Punica granatum Linn. (Punicaceae) are important medicinal plants in Iranian traditional medicine (Unani) whose have been used as remedy against edema, bum, wound and for their carminative, antimicrobial and anti-inflammatory activities. The diethyl ether extract of M. sylvestris and P. granatum flowers were used to evaluate the wound healin...

Chronic, non-healing wounds are a major complication of diabetes. Recently, various cell therapies have been reported for promotion of diabetic wound healing. Epidermal stem cells (ESCs) are considered a powerful tool for tissue therapy. However, the effect and the mechanism of the therapeutic properties of ESCs in the diabetic wound healing are unclear. Herein, to determine the ability of ESCs...

Diabetes impairs the ability to heal cutaneous wounds, leading to hospitalization, amputations, and death. Patients with diabetes experience elevated levels of plasminogen activator inhibitor 1 (PAI-1), regardless of their glycemic control. It has been demonstrated that PAI-1-deficient mice exhibit improved cutaneous wound healing, and that PAI-1 inhibition improves skeletal muscle repair in mi...

The potential role of omega – 3 (ω-3) and omega - 6(ω-6) fatty acids on wound healing is of interest and controversial. In the present study, the effect of dietary intake of fish oil (ω-3 diet ) and corn oil (ω-6 diet) on skin wound healing has been investigated in rat. This experimental study was performed on four groups of male rats (one normal group and three diabetic groups). Diabetes was i...

metalloproteinases and tissue inhibitors of matrix metalloproteinases at multiple levels of regulation. Retardation of wound healing is one of complications in diabetes mellitus due to increased collagenase activity and reduced granulation tissue in the diabetic wound. Studies on wound healing in streptozotocin (STZ)-induced diabetic rats suggested the possibility that the reduced breaking woun...

Diabetic wounds are unlike typical wounds in that they are slower to heal, making treatment with conventional topical medications an uphill process. Among several different alternative therapies, honey is an effective choice because it provides comparatively rapid wound healing. Although honey has been used as an alternative medicine for wound healing since ancient times, the application of hon...

Impaired wound healing is a common complication associated with diabetes with complex pathophysiological underlying mechanisms and often necessitates amputation. With the advancement in laser technology, irradiation of these wounds with low-intensity laser irradiation (LILI) or phototherapy, has shown a vast improvement in wound healing. At the correct laser parameters, LILI has shown to increa...

Objective-This study was conducted to evaluate the effect of co-administration of Aloe vera gel and cinnamon zeynalicum bark hydroethanolic extract on process of wound healing in diabetic mice model.Design- Experimental Study.Animals- Seventy-two male BALB/c mice.Procedures- A single full-thickness excisional wound was created on ba...

wound site plays an essential role in wound healing as these can contribute directly to vasculogenesis.This process is dysregulated in diabetic wounds. It has been shown that injury-induced Hoxa3 expression is impaired in diabetic mice and this affects the recruitment of cells to the wound. Restoration of Hox transcription factor results in a decrease in inflammatory cell (CD45+) and an increas...