OBJECTIVE To study the nerve conduction velocity in clinically undetectable and detectable peripheral neuropathy in type 2 diabetes mellitus with variable duration. MATERIAL AND METHODS This cross sectional study was conducted in diagnosed type 2 diabetes mellitus patients. They were divided in groups: Group I (n=37) with clinically detectable diabetic peripheral neuropathy of shorter duratio...

BACKGROUND Considerable studies directly connect the complications in diabetic patients, and especially peripheral neuropathy, with the emergence of depression. Neuropathetic pain may deteriorate the general health status of the diabetic patient and glycaemic regulation. PURPOSE The purpose of this study was to investigate the appearance and degree of diabetic peripheral neuropathy and its co...

Biological substances with neurotrophic activities, such as nerve growth factor (NGF) and monosialoganglioside GM1, have been considered as agents for diabetic peripheral neuropathy. Because recent studies have suggested that decreased availability of these substances might contribute to the pathogenesis of diabetic peripheral neuropathy, some clinical trials of NGF for diabetic peripheral neur...

The present study evaluated the effectiveness of micronized palmitoylethanolamide (PEA-m) treatment in reducing the painful symptoms experienced by diabetic patients with peripheral neuropathy. PEA-m, a fatty acid amide of the N-acylethanolamine family, was administered (300 mg twice daily) to 30 diabetic patients suffering from painful diabetic neuropathy. Before treatment start, after 30 and ...

The majority of foot ulcers appear to result from minor trauma in the presence of sensory neuropathy. This best describes the critical triad most commonly seen in patients with diabetic foot ulcers: peripheral sensory neuropathy, deformity, and trauma. All three of these risk factors are present in 65% of diabetic foot ulcers. Calluses, edema, and peripheral vascular disease have also been iden...

Type 2 Diabetes mellitus is a disease which manifests with a variety of cardiovascular risk factors, including hypertension, dyslipidemia and overweight or obesity that contributes to development of long term complications termed diabetic related ailments. Diabetic peripheral neuropathy (DPN) is a debilitating condition affecting as many as one half of all patients with diabetes during the cour...

BACKGROUND There are marked ethnic differences in the susceptibility to the long-term diabetic vascular complications including sensory neuropathy. The vascular endothelial growth factor (VEGF) +405 (C/G) and -460 (T/C) polymorphisms are associated with retinopathy and possibly with nephropathy, however no information is available on their relationship with peripheral neuropathy. Therefore, we ...

Introduction: Diabetes mellitus impairs the metabolism of carbohydrates, lipids and proteins, which leads to the dysfunction of the central and peripheral nervous system. This study evaluates the effects of an aloe vera hydro-alcoholic extract on diabetic neuropathy. Materials and Methods: For this study, 48 healthy male Sprague Dawley rats(weighed 250-200 g) were randomly divided in to t...