Abstract Chronic granulomatous disease (CGD) is characterized by recurrent bacterial and fungal infections due to reduced nicotinamide adenine dinucleotide phosphate oxidase resulting in impaired production of reactive oxidant species, aberrant inflammation. X-linked CGD (XL-CGD) associated with a mutation the CYBB gene. XL-CGD affects more males, although some females are affected skewed X-ina...

OBJECTIVE To investigate the association of gestational age and mode of birth with early child development. METHODS Population-based record linkage cohort study was conducted among 153 730 live-born infants of ≥32 weeks' gestation with developmental assessments at school age, in New South Wales, Australia, 2002 to 2007. Children were assessed in 5 domains: physical health and well-being, lang...

Background: Who can or cannot claim to represent other members within the disability rights movement has been discussed for decades, mainly concerning being disabled as an eligibility prerequisite. Aim(s): The aim is analyse arguments representational claims a Swedish organisation (DHR, Disability Human Rights). Method: Every member of DHR was given opportunity answer three open-ended questions...

The insect neuropeptide family FXPRLa, which carries the Phe-Xaa-Pro-Arg-Leu-NH2 sequence at the C-terminus, is involved in many physiological processes. Although ligand-receptor interactions in FXPRLa signaling have been examined using in vitro assays, the correlation between these interactions and in vivo physiological function is unclear. Diapause in the silkworm, Bombyx mori, is thought to ...

Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a considerable burden of morbidity and mortality not only driven by the reactions themselves but also by the use of alternatives which are sometimes less effect...

Input devices are often evaluated in terms of their throughput, as measured by Fitts' Law, and by their resolution. However, little effort has been made to understand the limit of resolution that is controllable or “usable” by the human using the device. What is the point of a 5000 dpi computer mouse if the human motor control system is far from being able to achieve this level of precision? Th...

Every child had an average of three episodes of diarrhea per year in developing countries in the twentieth century. The decrease of the number of deaths due to diarrhea in Brazil was more closely related to the use of control techniques than to changes in lifestyle conditions. This article seeks to analyze the spatial distribution of morbidity due to diarrhea among children and its relation wit...

It has been shown that hypercholesterolemia (HCh) exaggerates the microvascular dysfunction that is elicited by ischemia and reperfusion (I/R). The objective of this study was to determine whether oxidants contribute to the exaggerated inflammatory responses and enhanced albumin leakage observed in HCh rat mesenteric venules exposed to I/R (10 minutes of ischemia and 30 minutes of reperfusion)....

Maslinic acid (MA) is a natural compound whose structure corresponds to a pentacyclic triterpene. It is abundant in the cuticular lipid layer of olives. MA has many biological and therapeutic properties related to health, including antitumor, anti-inflammatory, antimicrobial, antiparasitic, antihypertensive, and antioxidant activities. However, no studies have been performed to understand the m...