The herb kava has recently been associated with numerous drug interactions, but its interaction with cytochrome P450 (P450) enzymes has not been investigated. In the present work the inhibition of P450 enzymes by kava extract and individual kavalactones in human liver microsomes (HLMs) was investigated. Whole kava extract (normalized to 100 M total kavalactones) caused concentration-dependent d...

Research in Human-Computer Interaction (HCI) has been enormously successful in the area of computeraided ergonomics or human-centric designs. Perfect fit for people has always been a target for product design. Designers traditionally used anthropometric dimensions for 3D product design which created a lot of fitting problems when dealing with the complexities of the human body shapes. Computer ...

The herb kava has recently been associated with numerous drug interactions, but its interaction with cytochrome P450 (P450) enzymes has not been investigated. In the present work the inhibition of P450 enzymes by kava extract and individual kavalactones in human liver microsomes (HLMs) was investigated. Whole kava extract (normalized to 100 microM total kavalactones) caused concentration-depend...

We propose a novel dynamic host mutation (DHM) architecture based on moving target defense (MTD) that can actively cope with cyberattacks. The goal of the DHM is to break the cyber kill chain, expand the attack surface to increase the attacker’s target analysis cost, and disrupt the attacker’s fingerprinting to disable the server trace. We define the participating entities that share the MTD po...

Automated label-free quantitative imaging of biological samples can greatly benefit high throughput diseases diagnosis. Digital holographic microscopy (DHM) is a powerful quantitative label-free imaging tool that retrieves structural details of cellular samples non-invasively. In off-axis DHM, a proper spatial filtering window in Fourier space is crucial to the quality of reconstructed phase im...

Process discovery methods automatically infer process models from event logs. Often, event logs contain so-called noise, e.g., infrequent outliers or recording errors, which obscure the main behavior of the process. Existing methods filter this noise based on the frequency of event labels: infrequent paths and activities are excluded. However, infrequent behavior may reveal important insights i...

OBJECTIVES Flavanol dihydromyricetin (DHM) has been shown to counteract acute ethanol (EtOH) intoxication and reduce excessive EtOH consumption. Since this flavonoid is being considered for human use, the in vivo study of DHM interactions with the cytochrome P450 (CYP) multienzyme system in the respect of metabolic activation of a model food-born carcinogen, benzo[a]pyrene (BaP), is of high imp...

Microscope has been widely used to observe microscopic objects. The types of microscope are varied according to its function. The conventional optical microscope only provides intensity information of an object and it has some difficulties to provide information about the real shape of the object and the projection of the object in different depth and perspective. In addition, optical microscop...

For the first time, the latent heat of fusion DHm for Sn particles formed by evaporation on inert substrate with radii ranging from 5 to 50 nm has been measured directly using a novel scanning nanocalorimeter. A particle-size-dependent reduction of DHm has been observed. An “excluded volume” is introduced to describe the latent heat of fusion from the enhanced surface melting of small particles...

Background Donor human milk (DHM) has been identified as a subject with widely differing regulatory approaches in different European countries and no regulation some. Up to date, information about the actual legal classification of DHM is not available from literature.