a rapid infusion of dextran. Cardiac output returned to normal in 20 patients and shock or hypotension was corrected in 16. In 10 patients with evidence of vasoconstriction and normal cardiac function, dextran reversed the circulatory abnormality, returning blood pressure, cardiac output, and peripheral vascular resistance to normal. Twelve patients with hypotension without evidence of reflex v...

Thirty ml of 6% dextran (mol wt 70,000) was given intravenously daily to rabbits that were hypercholesterolemic from the ingestion of a 0.5%-cholesterol diet. Serum cholesterol concentrations were reduced from 990 ± 103 mg/100 ml to 676 it 79 mg/100 ml after 3 days and to 331 ± 35 mg/100 ml after 7 days of dextran treatment. With the cessation of dextran infusions, serum cholesterol levels rose...

Dendritic cells (DCs) are essential mediators of the host immune response to surrounding microbes. In this study, we investigate the role of DCs in the pathogenesis of a widely used colitis model, dextran sulfate sodium-induced colitis. The effect of dextran sulfate sodium on the production of proinflammatory cytokines and chemokines by bone marrow-derived DCs (BM-DCs) was analyzed. BM-DCs were...

Cationic dextran hydrogels having pendent 51-59 mol% N-alkyl-N,N-dimethylammonium chloride groups were synthesized and tested as adsorbents for sodium cholate. The bile acid salt sorption by these gels was evaluated equilibrium analysis in water 10 mM NaCl solution. best adsorption results obtained with amphiphilic dextran-based two types of pendant ammonium different polarities. Experimental d...

tion after low molecular weight dextran infusion in sheep. Med J Austr 18: 539-541, 1967 31. Cox EF, Flotte CT, Buxton RW: Dextran in the treatment of thrombophlebitis. Surgery 57: 225-229, 1965 32. Weiss HJ: Antiplatelet therapy. N Eng J Med 298: 1344-1347, 1978 33. Bygdeman S: Experimental studies on the antithrombotic effect of dextran. Acta Chir Scand 387: (Suppl) 44-52, 1968 34. Boschenste...

Biodegradable polyesters, such as the poly(lactic-co-glycolic acid) (PLGA), have been extensively used a polymer matrix for entrapping variety of active compounds. In this study, physicochemical phenomena that control mass transport mechanism hydrophilic compounds released from PLGA microspheres were identified. This study aims to produce and characterize loaded with metformin hydrochloride (MH...

The effect of dextran sulfate on protein aggregation was investigated to provide the clues of its biochemical mechanism. The interaction between dextran sulfate and BSA varied with the pH values of the solution, which led to the different extent of aggregation prevention by dextran sulfate. Light scattering data with thermal scan showed that dextran sulfate suppressed BSA aggregation at pH 5.1 ...

In response to the high levels of dextran being obtained in raw sugars produced at Jamaican sugar factories, newer methods have been investigated to assess the accuracy and appropriateness for routine analysis of dextran in factory products. Two methods, the Dextran And Sucrose Assay (DASA) developed by Optical Activity® with field work in Jamaica and the Monoclonal Antibody (MCA) test develope...

In the work the thermal behaviour of the magnetic nanoparticles modi ed with polysaccharide dextran of di erent weight ratios to the magnetite Fe3O4 was investigated using thermoanalytical methods di erential scanning calorimetry and thermogravimetric analysis. The adsorption of dextran on the magnetic nanoparticles was con rmed and the in uence of the dextran amount in the modi ed magnetic uid...