Mol-ecules in the title compound, C(4)H(7)N(2) (+)·C(4)H(3)O(4) (-), are linked by inter-molecular N-H⋯O hydrogen bonds into one-dimensional chains parallel to [101]. These chains are in turn linked by an R(2) (2)(8) motif, formed by weak C-H⋯O hydrogen bonds, into corrugated sheets running parallel to (10). These sheets are further linked by weak inter-molecular C-H⋯O hydrogen bonds, forming a...

In the title salt, C5H14N2 (2+)·2C4H3O4 (-), the asymmetric unit contains two independent 2-methyl-piperazinium dications, which comprise a racemic pair, and four hydrogen maleate monoanions. In the roughly planar hydrogen maleate anions, intra-molecular O-H⋯O hydrogen bonds generate S(7) rings. In the crystal, the four independent anions are linked to the 2-methyl-piperazinium cations through ...

In this study, synthesis of unsaturated Poly(2-Butene Maleate) polyester by condensation polymerization and preparation cross-linked graft copolymer with methyl methacrylate are presented. For purpose, polyesters were synthesized in four different time periods (12h, 24h, 36h, 48h) the presence hydroquinone using 1,4-Butanediol-2-ene maleic anhydride. Then, obtained was purified on alumina colum...

A 70-year-old man with glaucoma was treated with eyedrops containing timolol maleate and brimonidine tartrate for >2 years. The patient presented with erythematous and oedematous pruritic lesions on both cheeks (Fig. 1a). Patch testing was performed with the Spanish Contact Dermatitis Research Group baseline series (TRUE Test®; Stallergenes Ibérica, Madrid, Spain; Brial Allergens GmbH,Greven, G...

INTRODUCTION Travoprost 0.004%/timolol maleate 0.5% fixed combination eye drops are available in Japan. We prospectively investigated the intraocular pressure (IOP)-decreasing effect of travoprost 0.004%/timolol maleate 0.5% fixed combination eye drops and the adherence of patients to the administration protocol. MATERIALS AND METHODS We studied 43 eyes from 43 patients diagnosed with primary...

BACKGROUND Latanoprost 0.005% + timolol maleate 0.5% combined eyedrops were recently made available in Japan. We prospectively investigated the intraocular pressure (IOP)-lowering effect, visual preservation effect, and adverse reactions of a one-year administration of this fixed combination. METHODS The subjects included 162 eyes from 162 patients diagnosed with either primary open-angle gla...

Pullulan, a water soluble, bioadhesive and biocompatible biopolymer is used as an efficient matrix for enalapril maleate film preparation. The obtained film contains as much as 67% of enalapril maleate, relative to the initial amount used for experiments. The drug content was evaluated by using 1 H-NMR and UV-vis spectroscopy. The pullulanenalaprilmaleate blends exhibit good physicochemical pro...

Conditions for determination of: ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method in substances and pharmaceuticals were provided. Maximum wavelenghts were: 228 nm for ketotifen hydrogen fumarate, 295 nm for azelastine hydrochloride, 265 nm for dimetindene maleate and 255 nm for promethazine hydrochloride. The limi...

Three different sensitive and accurate spectroscopic procedures were developed for the determination of three angiotensin-converting enzyme inhibitors, namely, ramipril, enalapril maleate and fosinopril. The first two spectrophotometric (extractive and non-extractive) procedures were based on ternary complex formation with molybdenum(V) thiocyanate. The formed complex can be determined by extra...