We recently demonstrated that three antigen-presenting cell (APC) subsets exist in the healthy human dermis, CD14(+) and CD1a(+) dermal APCs and migratory dermal Langerhans cells. Here, we extend these findings by defining CD208 as an exclusive marker of migratory dermal Langerhans cells, confirming that migratory dermal Langerhans cells (CD1a(high) CD207(+) CD208(+)) and CD1a(+) dermal APCs (C...

BACKGROUND Dermal metastases in squamous cell carcinomas of the head and neck are rare. The purpose of this study was to evaluate incidence, site, prognostic significance, and treatment modalities of dermal metastases of squamous cell carcinoma of the head and neck. METHODS Medical records were retrospectively analyzed. Statistical analysis was performed using Fisher exact test, Cox regressio...

Melanoma is the most aggressive and treatment-resistant of all human skin cancers responsible for approximately 80% cancer mortalities. Melanoma, initiates within epidermis; during progression, cells invade into dermis become primary metastatic through blood vessels lymphatic system. First develop growth occurs by spreading to their draining nodes via vessels, but mechanism not fully understood...

The volumes of the dermal papilla, matrix and fully grown hair of vibrissal follicles of rats and mice were measured. Dermal papillae were surgically removed from rats' vibrissal follicles and a small new dermal papilla was always reformed. The lower third of rats and mice follicles, containing the whole of the dermal papilla was amputated and very small dermal papillae were reformed. Follicles...

Tissue-engineered skin constructs correct vascularization remains a major challenge. We have shown that the presence of dermal papilla cells (DPCs) in these favors process, resulting better wound healing and graft take. To culture DPC as spheres increases expression angiogenic genes such VEGF, angiogenin FGF. Since angiogenesis scaffolds is essential for grafts to survive integrate with existin...

Minimally invasive procedures are becoming increasingly more common in surgery. However, the biomaterials capable of delivering biomimetic, three-dimensional (3D) functional tissues a minimally manner and exhibiting ordered structures after delivery lacking. Herein, we reported fabrication gelatin methacryloyl (GelMA)-coated, 3D expanded nanofiber scaffolds, their potential applications tissue ...

Abstract Background Diabetic wounds threaten the health and quality of life patients their treatment remains challenging. ADSC-derived exosomes have shown encouraging results in enhancing diabetic wound healing. However, how to use effectively is a problem that needs be addressed at present. Methods A mouse skin model was established. (ADSC-Exos) were isolated, vitro application evaluated using...

Feathers are complex assemblages of multiple morphological innovations. Recent research on the development and evolution of feathers has produced new insights into the origin and diversification of the morphological innovations in feathers. In this article, I review and discuss the contribution of three different factors to the evolution of morphological innovations in feathers: feather tubular...

The purpose of the present investigation was to study the effects of ionizing radiation on endothelial cells derived from diverse normal tissues. We first compared the effects of radiation on clonogenic survival and tube formation of endothelial cells, and then investigated the molecular signaling pathways involved in endothelial cell survival and angiogenesis. Among the different endothelial c...

Angiogenesis is implicated in diverse pathological conditions such as cancer, rheumatoid arthritis, psoriasis, atherosclerosis, and retinal neovascularization. In the present study, we investigated the effects of modified rice bran hemicellulose (MRBH), a water-soluble hemicellulose preparation from rice bran treated with shiitake enzymes, on vascular endothelial growth factor (VEGF)-induced an...