There is considerable heterogeneity in antidepressant treatment response across individuals. As people with depression may manifest different symptom profiles, we hypothesized that the constellation of specific depressive symptoms might explain some response. To assess this hypothesis, examined symptom-specific remission related to vs placebo among those and without a Data were from 19 randomiz...

Exposure to early life trauma is a known risk factor for depression and anxiety disorders in adulthood. This study aimed to evaluate the relative contributions of early life versus adult trauma in predicting levels of depressive and anxiety symptoms in nonclinical community adults. 1209 nonclinical community adults (18-70 years; 45% male) were assessed for mental health status, early life stres...

INTRODUCTION The question of whether abstinence during the months following a planned quit attempt exacerbates or improves depressive symptoms is an important clinical issue. Extant research has primarily modeled between-person covariation between postquit abstinence and depressive symptom trajectories. However, this approach cannot account for potential third variables between participants tha...

BACKGROUND Many individuals with schizophrenia experience remission of prominent positive symptoms but continue to experience impairments in real world functioning. Residual negative and depressive symptoms may have a direct impact on functioning and impair patients' ability to use the cognitive and functional skills that they possess (competence) in the real world (functional performance). M...

BACKGROUND Panic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity. METHODS Using data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compared entry and post-SSRI-treatment QOL, functioning, and depressive symptom sev...

We analyzed depressive and psychosomatic symptoms in relation to co-twin dependence in 419 twins at the age of 22 to 30 years. Depressive symptoms were assessed, as previously, with Children's Depression Inventory modified to be suitable for this age and reported as a total score and three subscales (low self-confidence, anhedonia and sadness) based on factor analysis as reported in a previous ...

Deficits in emotion regulation have been identified as an important risk and maintaining factor for depression. The aim of this study was to examine the long-term effects of emotion regulation on symptoms of depression. Moreover, we investigated which specific emotion regulation skills were associated with subsequent symptoms of depression. Participants were 116 individuals (78% women, average ...

OBJECTIVE Some researchers have reported that distribution of total depressive symptom scores in the general population may follow an exponential pattern except at the lowest end of the scores. To understand the mechanism responsible for this phenomenon, we investigated the mathematical patterns of the individual distributions for each item of a depressive symptom scale. METHODS We analysed d...

The need to identify and improve access to evidence-based treatments for depressive disorders and other mental health problems is a public health priority, particularly in relation to racial/ethnic minorities and other underserved groups. One hundred forty-six Mexican American primary care patients who met diagnostic criteria for major depressive disorder, dysthymic disorder, or depressive diso...

This study aimed to examine cross-sectionally to what extent persons with higher symptom levels or a current or past emotional disorder report to be less happy than controls and to assess prospectively whether time-lagged measurements of extraversion and neuroticism predict future happiness independent of time-lagged measurements of emotional disorders or symptom severity. A sample of 2142 adul...