conclusions the occurrence of he is associated with hyponatremia and ppi use in patients with aclf. results in univariate analysis, patients with he in aclf had a significantly higher rate of ppi use (89.1%) compared with non-he (63.6%, p = 0.001). in addition, clinical and standard laboratory variables were significantly different between the two groups regarding the infection rate, hyponatrem...

abstract digestive enzyme inhibitors are proteinacious or nonproteinacious compounds which reduce an enzyme activity through attaching to its active site and/or its substrate. nowadays, plant enzyme inhibitors are of great importance because 1) these have considerable effects on insect digestive enzymes and as a result on their development; and 2) the transgenic plants expressing them are safe....

objective(s):pantoprazole, is a proton pump inhibitor (ppi) prescribed for the treatment of upper gastrointestinal disorders, which in high doses has been suggested to decrease calcium absorption leading to hypocalcaemia and therefore osteoporosis. the aim of this study was to assess whether pantoprazol, could alter the rate of orthodontic tooth movement (otm) in rats. materials and methods: a ...

introduction: tyrosine kinase inhibitors (tkis) were the first drugs to use an intracellular signaling molecule as a therapeutic target. unresponsiveness to tkis limits therapeutic options, making allogeneic hematopoietic stem cell transplantation (hsct) the only option leading to molecular remission. objectives: to characterize cml patients unresponsive to first- and/or second-generation tki t...

An efficient and rapid affinity-based screening method for directly fishing out natural alpha-glucosidase inhibitors from Cyperus. rotundus extract by using immobilized enzyme technology combined with UHPLC-QTOF MS analysis was established. As a results, without time-consuming and laborious isolation workload and false positive interference, five natural alpha-glucosidase inhibitors were succes...

Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...

The corrosion inhibition properties of the benzothiazole BTH and benzotriazole BT inhibitors on the aluminum in 0.25 M HCl solution were studied. Electrochemical impedance spectroscopy EIS, electrochemical noise EN and potentiodynamic polarization techniques were used to investigate the inhibition properties of the inhibitors. Scanning electron microscope SEM was also utilized in order to inves...

Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...

Background: Changing the mental structure of students and identifying creativity inhibitors are essential for academic survival and the pursuit of innovation. This study aimed to identify the inhibitory cognitive factors in medical students. Methods: This study was a directional qualitative content analysis that conducted based on scientific literature review and opinions of experts in a semif...

the objective of this meta-analysis was to compare effects of chemical methanogenic inhibitors on fermentation parameters in ruminal batch cultures. nine published in vitro studies including 26 treatment means in which 2-bromoethane sulfonate, bromochloromethane and 9,10-anthraquinone were used as methanogens inhibitor compared in amount of ch4, h2, total volatile fatty acid, actate, propionate...