Dengue virus (DENV) is a member of the Flavivirus genus of the Flaviviridae family of enveloped, positive-strand RNA viruses. The Flavivirus genus includes viruses transmitted by mosquitoes and ticks, as well as zoonotic agents with no known arthropod vector. In addition to DENV, flaviviruses that are significant threats to human health include yellow fever virus, West Nile virus (WNV), Japanes...

BACKGROUND Diabetes mellitus is known to exacerbate bacterial infection, but its effect on the severity of viral infection has not been well studied. The severity of thrombocytopenia is an indicator of the severity of dengue virus infection. We investigated whether diabetes is associated with thrombocytopenia in dengue-infected patients. METHODS We studied clinical characteristics of 644 pati...

Dengue is one of the most common mosquito-borne viral illnesses in tropical areas, including Pakistan. Presentation varies from a self-limiting flu-like illness to life-threatening conditions like hemorrhagic shock and multi-organ dysfunction leading death. In absence vomiting diarrhea, electrolyte abnormalities are rare findings. Though Guillain-Barré syndrome known association presenting with...

Dengue virus (DENV) is a vector-borne viral disease that cause more human morbidity and mortality worldwide than any other arthropod-borne virus. It is estimated that 3.97 billion people living in 128 countries are at risk of dengue, 400 million infections annually, and 96 million asymptomatic cases occurring every year [1-4]. Four closely related dengue serotypes cause the disease: DENV-1 to -...

Title: Should colloid boluses be prioritized over crystalloid boluses for the management of dengue shock syndrome in the presence of ascites and pleural effusions? I have addressed all the comments raised by reviewers and highlighted in the text. In addition, I have included some of my views below to some of the referees comments which I have not included in the text. Second revision: Paper ent...

Dengue fever is an endemic illness in the tropics with early and post infectious complications affecting multiple systems. Though neurological sequelae including mononeuropathy, encephalopathy, transverse myelitis, polyradiculopathy, Guillain-Barre syndrome , optic neuropathy and oculomotor neuropathy have been reported in medical literature, the abducens nerve despite its notoriety in cranial ...

OBJECTIVE To investigate the patterns of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, interferon-gamma (IFN-gamma) and interleukin-1 receptor antagonist (IL-1Ra) during the course of dengue shock syndrome. DESIGN Prospective clinical study. SETTING Pediatric Intensive Care Unit, Dr. Kariadi Hospital, the university hospital of Diponegoro University, Semarang,...

During the past two decades, dengue viruses have been a major cause of severe illness and death among children in tropical Asia (1). Dengue viruses are mosquito-borne flaviviruses which occur as four antigenically distinct types. Homotypic immunity is thought to be life long, but after a brief period of crossprotection, heterotypic infections occur and are accompanied by secondary-type antibody...

To determine the magnitude of the problem posed by primary dengue infection in children and the distinctive clinical clues that may differ from those with secondary infection, 996 children serologically diagnosed with dengue infection and admitted to the Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand between 1988 and 1995 were retrospectively reviewed. One hundred and thirt...

To find out predictive value of elevated liver transaminases as a predictor poor maternal outcome in pregnant women with dengue infection. Our study was retrospective study, conducted tertiary care centre North India from July 1 to December 31, 2021. Data all the infection during above period screened for and fetal outcomes. Elevated who developed DHF, DSS mortality were main measures. Mode del...