In numerical simulations where complex fracture behavior plays a prominent role in the material’s mechanical behavior, particle methods are an attractive computational tool since they adequately accommodate arbitrary discontinuities. However, existing either limited their constitutive flexibility, like Discrete Element Method (DEM), or prone to instabilities, Smoothed Particle Hydrodynamics (SP...

Thrombosis is a life-threatening complication of hemolytic anemia in humans. Cardiac thrombi are present in all adult a-spectrin–deficient (sph/sph) mice with severe hereditary spherocytosis, providing a model for events preceding thrombosis. The current study evaluated (1) the timing of thrombosis initiation and (2) the effect of postnatal transplantation of normal cells on life span and throm...

Thrombosis is a life-threatening complication of hemolytic anemia in humans. Cardiac thrombi are present in all adult alpha-spectrin-deficient (sph/sph) mice with severe hereditary spherocytosis, providing a model for events preceding thrombosis. The current study evaluated (1) the timing of thrombosis initiation and (2) the effect of postnatal transplantation of normal cells on life span and t...

We present a new algorithm for simulating two-fluid gas and dust mixtures in Smoothed Particle Hydrodynamics (SPH), systematically addressing a number of key issues including the generalised SPH density estimate in multi-fluid systems, the consistent treatment of variable smoothing length terms, finite particle size, time step stability, thermal coupling terms and the choice of kernel and smoot...

We report on the synthesis of the Discrete Element Method (DEM) modelling the behaviour of granular materials and a finite volume model for the continuous interstitial fluid using Computational Fluid Dynamics (CFD). DEM captures the physics of granular materials best but is computationally time-consuming. For this reason, the DEM is complemented by a Discrete Phase Model (DPM) for disperse gran...

Ž . This study presents a computational method combining smoothed particle hydrodynamics SPH and the discrete element method Ž . DEM to model flows containing a viscous fluid and macroscopic solid particles. The two-dimensional numerical simulations are validated by comparing the wake size, drag coefficient and local heat transfer for flow past a circular cylinder at Reynolds numbers near 100. ...

Spheroidin (SPH) is the most highly expressed gene of the entomopoxvirus isolated from Amsacta moorei (AmEPV). The level of expression of poxvirus genes is believed to be governed in large part by the promoter. Poxvirus promoters generally consist of approximately 40 bp which frequently terminate at the 3' end with a translation initiating TAAATG sequence. We have examined the requirements for ...