Obwohl einige der Mechanismen, die zum Knochenschwund bei rheumatoider Arthritis (RA) führen, geklärt sind, ist genaue Beziehung zwischen Immunpathogenese RA und Osteoporose noch unklar. Einer wichtigsten serologischen Marker das Vorhandensein von Antikörpern gegen citrullinierte Proteine (ACPAs). Amkreutz et al. untersuchten in dieser Studie den Zusammenhang Autoantikörpern Knochenmineraldichte.

PURPOSE RPE65 is critical for the normal formation of 11-cis retinal and thus photoreceptor function. Opsin expressed in HEK293 cells has been reported to form rhodopsin on the addition of all-trans retinol, indicating that the machinery for retinoid isomerization is present. RPE65 has been previously identified in HEK293 cells at both the RNA and protein levels. To further understand retinoid ...

Rheumatoid arthritis (RA) is a systemic autoimmune disease of unknown etiology, characterized by chronic joint inflammation that often leads to joint destruction. Diagnosis of RA is currently based on the revised classification criteria of the American College of Rheumatology (ACR); however, it remains imprecise, especially early in the course of disease. Rheumatoid factor (RF) has been widely ...

INTRODUCTION Retinoic acid (RA) signaling is a well known regulator of trophoblast differentiation and placental development, and maternal decidual cells are recognized as the source of much of this RA. We explored possible trophoblast-derived sources of RA by examining the expression of RA synthesis enzymes in the developing mouse placenta, as well as addressed potential sites of RA action by ...

Abstract Autophagy is an evolutionarily conserved degradation process that degrades damaged proteins to maintain homeostasis and protect cells against stress. In this study, we identified characterized a critical autophagy-related protein, UvAtg14, in Ustilaginoidea virens , which the ortholog of MoAtg14 rice blast fungus Magnaporthe oryzea . UvAtg14 co-localized with UvAtg8 (an autophagy marke...

OBJECTIVE Two interferon regulatory factor 5 (IRF5) gene variants were examined for association with rheumatoid arthritis (RA). METHODS A total of 2300 patients with RA and 1836 controls were recruited from 2 independent RA studies in Sweden. One insertion-deletion polymorphism (CGGGG indel) and one single-nucleotide polymorphism (rs10488631) in the IRF5 gene were genotyped and analyzed withi...