To study the role of herpes simplex virus type 1 immediate-early proteins in the transcriptional activation of herpes simplex virus genes, we isolated stably transformed cells expressing herpes simplex virus type 1 ICP4, an immediate-early protein known from previous studies to be necessary for delayed-early and late transcription. These cells efficiently expressed six delayed-early herpes simp...

purpose : patients with infantile or childhood strabismus who do not achieve visual axes alignment early in life are believed to have poor prognosis with respect to the stereopsis. this study investigates the binocularity and stereopsis following delayed surgical alignment in patients with congenital and early-onset strabismus. patients & methods : 36 patients aged between 6-30 years participat...

conclusions: in this study, delay in diagnosis was similar to other studies. educating physicians to careful history taking especially in the case of ibp, non-musculoskeletal symptoms such as uveitis and precise physical examination are important in early diagnosis. patients and methods: sixty patients, (53 males, 7 females) with a diagnosis of as according to the modified new york criteria wer...

contact hypersensitivity (chs) mouse model induced by 2, 4-dinitrofluorobenzene (dnfb) is thought to be a t helper 1 (th1)-dominant response and used for investigating anti-inflammatory and immunosuppressive agents. however, it is hardly used for screening large-scale drugs because of the large number of animals and complex mechanisms involved in-vivo. in this study, we focused on whether t lym...

in this study, we investigate the immunostimulatory effects of alcoholic extract of the coffee seed on cell-mediated immune response andcyclophosphamide-induced (cp) immunosuppressed mice. the assessment of cellular immune function was carried out by the measurement of delayed-type hypersensitivity (dth) response. according to the literature survey, cyclophosphamide has only suppressing effect ...

objectives: the purpose of the present study is to investigate the oral narrative skills of late talkers mostly caused by mental disorders while they try to comprehend a wordless sequential picture story to create and narrate the relevant story. methods: to this end, 15 (10 male and 5 female) participants were who were the students of a specialized school for physically and mentally retarded st...

background although the immunosuppressant cyclosporine (csa) is widely used after kidney transplantation over the long term, there is still no firm consensus on the best way to monitor of csa blood levels. objectives cyclosporine (csa) assay is critical for the management of renal transplant recipients due to inter– and intra–patient variation in csa absorption and metabolism. patients and meth...

Abstract Endochondral bone formation is fundamental for skeletal development. During this process, chondrocytes undergo multiple steps of differentiation and coordinated transition from a proliferating to hypertrophic stage, which critical advance Here, we identified the transcription factor Dmrt2 (double-sex mab-3 related 2) as Sox9-inducible gene that promotes chondrocyte hypertrophy in pre-h...

Pressure ulcers are characterized by chronicity, which results in delayed wound healing due to pressure. Early intervention for preventing delayed healing due to pressure requires a prediction method. However, no study has reported the prediction of delayed healing due to pressure. Therefore, this study focused on biological response-based molecular markers for the establishment of an assessmen...

objective: patients over 60 years of age have higher mortality and morbidity after major liver resections. nitric oxide (no) derived from the catalytic activity of nos2 plays a beneficial role in liver regeneration (lr) after partial hepatectomy (ph). in this experiment, we evaluated the effect of nos2 knockout (ko) on lr in aged mice after ph. materials and methods: in this cohort study, 52 tw...