BACKGROUND Total disc replacement (TDR) using Mobi-C cervical artificial disc might be promising to treat symptomatic degenerative disc disease. However, the results remained controversial. We conducted a systematic review and meta-analysis to compare the efficacy and safety of Mobi-C cervical artificial disc and anterior cervical discectomy and fusion (ACDF) in patients with symptomatic degene...

BACKGROUND Degenerative diseases are a medical, social, and economic problem worldwide. The most significant factors predisposing the development of degenerative changes in intervertebral discs are a low density and poor biosynthetic potential of the cells. Therefore, stem cell therapy in this case should show high clinical efficiency. METHODS The research aim was to evaluate the regenerative...

background: a large proportion of patients presenting with lumbar disc disease are opium addicts in our region. it was, therefore, hypothesized that morphine might affect the intervertebral disc. we investigated the histological findings of morphine dependency on intervertebral discs in rat.   methods: forty nmri adult male rats (230-250 g) placed on ordinary diet and received aqueous solution ...

INTRODUCTION Artificial disc arthroplasty, as a promising treatment for disc degenerative diseases, has been reported to restore normal disc height, preserve segmental motion and decrease adjacent level degeneration. Despite its encouraging short term outcomes, complications related to device and surgical procedure such as subsidence, dislocation and instability due to misalignment warrant furt...

STUDY DESIGN Cross sectional and observational. PURPOSE To evaluate the different aspects of lumbar disc degenerative disc disease and relate them with magnetic resonance image (MRI) findings and symptoms. OVERVIEW OF LITERATURE Lumbar disc degenerative disease has now been proven as the most common cause of low back pain throughout the world. It may present as disc herniation, lumbar spina...

BACKGROUND Discectomies are a common surgical treatment for disc herniations in the canine spine. However, the effect of these procedures on intervertebral disc tissue is not fully understood. The objective of this study was to assess degenerative changes of cervical spinal segments undergoing discectomy procedures, in vivo. RESULTS Discectomies led to a 60% drop in disc height and 24% drop i...

OBJECTIVES Herniated discs and degenerative disc disease are major health problems worldwide. However, their pathogenesis remains obscure. This study aimed to explore the molecular mechanisms of these ailments and to identify underlying therapeutic targets. MATERIAL AND METHODS Using the GSE23130 microarray datasets downloaded from the Gene Expression Omnibus database, differentially co-expre...

AIMS This study is to determine if expression level of microRNA-143 (miR-143) and cyclooxygenase-2 (COX-2) are related to the occurrence and development of degenerative scoliosis. METHODS A total of 30 patients with degenerative scoliosis, 30 patients with adolescent idiopathic scoliosis were enrolled in this study. For control, 30 patients with spinal burst fractures were also enrolled in th...