PURPOSE A novel pulmonary ventilation imaging technique based on four-dimensional (4D) CT has advantages over existing techniques and could be used for functional avoidance in radiotherapy. There are various deformable image registration (DIR) algorithms and two classes of ventilation metric that can be used for 4D-CT ventilation imaging, each yielding different images. The purpose of this stud...

Deformable image registration is the spatial mapping of corresponding locations between images and can be used for important applications in radiotherapy. Although numerous methods have attempted to register deformable medical images automatically, such as salient-feature-based registration (SFBR), free-form deformation (FFD), and demons, no automatic method for registration is perfect, and no ...

Deformable image registration is a key enabling technology for advanced treatment of lung cancer patients, as it can facilitate motion estimation, structure segmentation, as well as dose tracking and accumulation. In this work, we developed a hybrid feature-constrained deformable registration method and applied it to tackle the EMPIRE10 (Evaluation of Methods for Pulmonary Image Registration 20...

In recent years one of the areas of interest in radiotherapy has been adaptive radiation therapy (ART), with the most efficient way of performing ART being the use of deformable image registration (DIR). In this paper we use the distances between points of interest (POIs) in the computed tomography (CT) and the cone beam computed tomography (CBCT) acquisition images and the inverse consistence ...

In this work, thirteen image-pairs, composed of a color fundus photograph and a scanning laser ophthalmoscope fluorescein angiography (SLO.FA), were registered by rigid, non-rigid and deformable image registration procedures to assess the need for deformable image registration methods when using SLO.FAmodalities. Each registration was quantitatively assessed by three different metrics that show...

The advent of readily available temporal imaging or time series volumetric (4D) imaging has become an indispensable component of treatment planning and adaptive radiotherapy (ART) at many radiotherapy centers. Deformable image registration (DIR) is also used in other areas of medical imaging, including motion corrected image reconstruction. Due to long computation time, clinical applications of...

For patients with locally-recurrent lung cancer, high dose thoracic re-irradiation can prolong survival. Deformable image registration improves the accuracy with which initial treatments are accounted for compared to rigid image registration. Using deformable image registration will improve correlative toxicity data, and may reduce toxicity for selected patients undergoing re-irradiation.