Chronic hepatitis C infection is an important cause of cirrhosis and hepatocellular carcinoma (HCC). Antiviral therapy (AVT) for patients with cirrhosis due to hepatitis C may retard the progression of cirrhosis and prevent both the development of HCC as well as the recurrence of hepatitis C following liver transplantation. This review highlights the issues associated with AVT for patients with...

In a series of 535 autopsies performed in the King George's Medical College Hospital, Vizagapatam, there were 50 cases (9.3 per cent) of cirrhosis of the liver. The material in this paper is based on a critical study of the autopsy findings in these 50 cases. The causes of cirrhosis of the liver in the 50 cases under discussion are given in the table. It will thus be seen from the table that, o...

Mortality in cirrhosis is consequent of decompensation, only treatment being timely liver transplantation. Organ allocation is prioritized for the sickest patients based on Model for End Stage Liver Disease (MELD) score. In order to improve survival in patients with high MELD score it is imperative to preserve them in suitable condition till transplantation. Here we examine means to prolong lif...

UNLABELLED Bacterial infections play an important role in liver cirrhosis complications, being together with variceal bleeding and hepatic encephalopathy an important cause of morbidity and mortality in cirrhotic patients. Spontaneous bacterial peritonitis (SBP) is a major complication of liver cirrhosis, with a significant mortality. Recent studies have demonstrated the involvement of oxygen f...

conclusions in hbeag positive chb patients, low serum hbsag level is a useful predictor of compensated cirrhosis. objectives the aim of our study was to evaluate serum hbsag level as a biomarker for compensated cirrhosis in hepatitis b e antigen (hbeag) positive chb patients. patients and methods two-hundred and one hbeag-positive chinese chb patients with or without cirrhosis were enrolled in ...

BACKGROUND There is limited data on the nutritional status of Asian patients with various aetiologies of cirrhosis. This study aimed to determine the prevalence of malnutrition and to compare nutritional differences between various aetiologies. METHODOLOGY A cross-sectional study of adult patients with decompensated cirrhosis was conducted. Nutritional status was assessed using standard anthr...

Chronic injury to the liver from a variety of different sources can result in irreversible scarring of the liver, known as cirrhosis. Cirrhosis is a major cause of morbidity and mortality in the USA, and according to the Centers for Disease Control and Prevention was responsible for 31,903 deaths in 2010 alone. It is thus of the utmost importance to appropriately manage these patients in the in...

Scope of the Problem In all disease states, early hospital readmissions are increasingly being viewed as a public health threat. Among the Medicare population, 19% of those discharged from an acute-care hospital are readmitted within 1 month, at a cost of> $17 billion, which represents nearly 20% of the Medicare budget. Patients discharged after a hospitalization for decompensated cirrhosis hav...

BACKGROUND Accurate evaluation of the glomerular filtration rate (GFR) in patients awaiting liver transplantation is important because they have a greater risk of impaired renal function. A major percentage of these patients have alcoholic cirrhosis, and the accuracy of bedside used GFR estimates have not been specifically evaluated in this group. The aim of this study was to evaluate the valid...

The pathogenesis of hepatic encephalopathy (HE) involves the interaction between two pathophysiological mechanisms: ammonia detoxification and inflammation. The neuropathology of HE is characterised by astrocyte dysfunction and swelling due to ammonia detoxification. The enzyme glutamine synthetase, which is located mainly in astrocytes, protects neurons by absorbing excess ammonia and glutamat...