Magnetic resonance imaging (MRI) is a widely used in-vivo imaging technique that is essential to the diagnosis of disease, but its longer acquisition time hinders its wide adaptation in time-critical applications, such as emergency diagnosis. Recent advances in compressed sensing (CS) research have provided promising theoretical insights to accelerate the MRI acquisition process, but CS reconst...

Introduction Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is an emerging technique for a more accurate assessment of local renal function [1]. Analysis of DCE-MRI time series is typically based on manual delineation of regions of interest in the recorded images. However, such procedures are time consuming, expensive and error prone [2,3], and subject to intraand interobserver ...

Dynamic Contrast Enhanced MRI (DCE-MRI) is today one of the most popular methods for tumor assessment. Several pharmacokinetic models have been proposed to analyze DCE-MRI. Most of them depend on an accurate arterial input function (AIF). We propose an automatic and versatile method to determine the AIF. The method has two stages, detection and segmentation, incorporating knowledge about artery...

Introduction. Dynamic contrast-enhanced MRI (DCE-MRI) has become an important tool in measuring tumour perfusion in animal models of cancer. Standard Kety model analysis of tumour perfusion [1] requires knowledge of the contrast agent concentration in the blood plasma, known as the arterial input function (AIF). Many DCE-MRI studies in mice use an assumed AIF taken from the literature (e.g. Lyn...

Rupture of a vulnerable atherosclerotic plaque of the carotid artery is an important underlying cause of clinical ischemic events, such as stroke. Abundant microvasculature has been identified as an important aspect contributing to plaque vulnerability. Plaque microvasculature can be studied non-invasively with dynamic contrast-enhanced (DCE-)MRI in animals and patients. In recent years, severa...

In many areas of oncology, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has proven to be a clinically useful, non-invasive functional imaging technique to quantify tumor vasculature and tumor perfusion characteristics. Tumor angiogenesis is an essential process for tumor growth, proliferation, and metastasis. Malignant lesions demonstrate rapid extravasation of contrast from t...

OBJECTIVE The objective of our study was to investigate whether dynamic contrast-enhanced MRI (DCE-MRI) can detect differences and potential adaption in single-kidney parenchymal volume, blood flow, glomerular filtration rate (GFR), and filtration fraction in the remaining kidney of healthy donors compared with nondonors. Further, we evaluated the agreement in donor GFRs measured using DCE-MRI ...

I. Overview Dynamic Contrast Enhanced MRI (DCE-MRI) is a rapidly evolving imaging technique. It is the current standard for breast MR imaging; also many research studies have been conducted to evaluate its application for various clinical problems. The development of gadolinium-based contrast agents in early 1980 opened a new era for imaging of tumors and vascular systems. Tumors require a high...

BACKGROUND Antiangiogenic treatment may change the tumor microenvironment and hence influence the effect of conventional therapies. The potential of diffusion weighted magnetic resonance imaging (DW-MRI) and dynamic contrast enhanced MRI (DCE-MRI) in assessing microenvironmental effects of sunitinib treatment was investigated in this preclinical study. METHODS Sunitinib-treated and untreated ...