background: one of the affecting factors in disturbance process of spermatogenesis is chemotherapeutic-induced oxidative stress resulted from cyclophosphamide (cp) treatment which leads to diminished sperm quality via interference in spermatogenesis process. objective: this study was conducted to investigate the effects of ethyl pyruvate (ep) in reducing the cp-induced side effects on reproduct...

objective(s):recent evidence have proposed that tretinoin produced in the gut preferentially promote differentiation of foxp3+treg cells but inhibits th17 lymphocytes, and this may be the main immunomdulatory mechanism of tretinoin  in vivo. this study was done to investigate the effects of tretinoin in outbred white mice after challenge with sheep red blood cells (srbc). materials and methods:...

glutamate-mediated excitotoxicity and neurodegeneration have been shown as pathophysiological hallmarks of multiple sclerosis (ms) and other autoimmune inflammatory cns disorders. n‑methyl‑d‑aspartate (nmda) receptors play a pivotal role in the mediation of neuronal glutamate excitotoxicity leading to cellular damage and apoptotic cell death. current treatment approaches targeting glutamate exc...

the use of liposome as an adjuvant and a vaccine carrier has been cited previously in the literature. it has also been shown to be effective in enhancing the immunogenicity of vaccine candidates. balb/c mice immunized subcutaneously with outer membrane protein (omp) of brucella abortus s19 vaccine strain entrapped in a commercial cationic liposome (s19-omp-liposome) for vaccine delivery, showed...

introduction: caloric restriction is a strategy applied for weight loss. water fasting is a popular way for obesity treatment. however, little is known about the impact of water fasting on weight. therefore, this study was conducted to investigate the effect of short-term, repeated water fasting on the weight of mice. methods: in this study, the physiological effect of short-term, repeated wate...

background: phenol is an estrogenic and toxic compound and people are widely exposed to it, in different ways.  objectives: the aim of this study was to determine  the  negative effects of phenol on the fertility of male mice, by investigating sperm parameters including viability, motility, fertility rates and daily sperm production (dsp). methods: a total of 106 adult nih mice were divided int...

reports indicate that one of the causes of harmful to the genital system, especially the testes is stress. result of damage to testicular quality certainly will affect the quality of sperm fertility. stress could be created secondarily after some pathological conditions such as neurological diseases or environmental factors. one of the causes of stress could be scary voices, such as cat voice f...

background there is still no suitable mice model that can completely mimic the human fulminant hepatitis, which sets a block for drug effect evaluation and mechanism researching of human fulminant hepatitis. objectives the aim of this study was to establish an animal model able to mimic the main features of human fulminant hepatitis. materials and methods dimethylnitrosamine (dmn) was peritonea...

conclusions our results demonstrated the promising prophylactic and therapeutic effects of propranolol against t. gondii infection. propranolol also increases the efficacy of pyrimethamine in combination therapies. results in the pre-treatment group, results showed that propranolol at 2 and 3 mg/kg combined with pyrimethamine was more effective in inhibiting growth of tachyzoites (86% and 98%, ...

background: indisputable population exposure to widespread electromagnetic fields, has grown concerns over the probable health effects of these fields. objective: the present study was aimed to examine the possible effects of 50 hz extremely low frequency electromagnetic field (elf-emf) exposure on the number and quality of mice blastocysts. materials and methods: in present study, 66 nmri preg...