نتایج جستجو برای: damage tolerance limit
تعداد نتایج: 532404 فیلتر نتایج به سال:
DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis, polyubiquitination activates an error-free pathway, elusive in mammals, enabling damage bypass by template switching. Fork reversal is driven in vitro by multiple enzymes, including the DNA translocase ZRANB3, shown to bind polyubiquitina...
Background & Aim: People with diabetes are potentially threatened by other factors such as negative emotions, nervous system defects, and sensitivity to anxiety, which affects whether or not they are affected by diabetes-related wounds. The aim of the study was to investigate the effect of brain-behavioral system on diabetic female patients exposed to psychological vulnerability with the mediat...
Global environmental quality decline builds up through innumerable decisions at many scales that cause damage to ecological and social values. Environmental assessment (EA) is a relevant decision-making framework in this sense. Besides its technical role, EA has cultural side we should consider the pursuit of sustainable societies. Despite limited reach, exemplifies confronts some implicit stan...
Resistance and tolerance are widely viewed as two alternative adaptive responses to herbivory. However, the traits underlying resistance and tolerance remain largely unknown, as does the genetic architecture of herbivory responses and the prevalence of genetic trade-offs. To address these issues, we measured resistance and tolerance to natural apical meristem damage (AMD) by rabbits in a large ...
The incidence of contamination of aflatoxin M1 (AFM1) in milk samples collected from the Jordanian market was investigated by using the competitive enzyme linked immunosorbent assay (ELISA) technique. A total of 175 samples were collected during 2014-2015. All tested samples were contaminated with various levels of AFM1 ranging from 9.71 to 288.68 ng/kg. The concentration of AFM1 in 66% of fres...
Winter cold is a significant damaging factor in fruit trees specially stone fruits. Relative resistance of 20 local and introduced sweet cherries (Prunus avium) to winter cold in artificial cold condition and its association with electrical conductivity and a number of morphological traits including trunk diameter, shoot diameter, anthocyanine and lenticels frequencies was studied in year 2011....
The effect of 5-thio-D-glucose on oxic and hypoxic V79-171 Chinese hamster cells was studied in vitro with single cells and multicell spheroids. At concentrations that were not toxic to oxic cells, this compound killed hypoxic cells with a D0 of 1 hr with a 5 mM concentration and more rapidly at 10 mM beginning 2 hr after incubation at 37 degrees. 5-Thio-D-glucose also sensitized hypoxic cells ...
Anhydrobiotic engineering aims to increase the level of desiccation tolerance in sensitive organisms to that observed in true anhydrobiotes. In addition to a suitable extracellular drying excipient, a key factor for anhydrobiotic engineering of gram-negative enterobacteria seems to be the generation of high intracellular concentrations of the nonreducing disaccharide trehalose, which can be ach...
Despite the increased focus on security, critical information systems remain vulnerable to cyber attacks. The trend lends importance to the concept of intrusion tolerance: there is a high probability that systems will be successfully attacked and a critical system must fend off or at least limit the damage caused by unknown and/or undetected attacks. In prior work, we developed a Self-Cleansing...
In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue, leading to two modes of DNA-damage tolerance, namely, translesion DNA synthesis (TLS) and error-free lesion bypass. Although the majority of reported data support a model whereby monoubiquitinated PCNA enhances its affinity for TLS polymerases and hence r...
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