conclusions among the treatment regimens containing dcv, dcv/sof has the highest svr rate for the treatment of infection with different hcv genotypes in different patient contexts; thus, this regimen shows promise for the treatment of hcv infections. results we found six different regimens containing dcv: dcv/asunaprevir (asv), dcv/asv/beclubavir, dcv/pegylated interferon lambda or alpha/rbv wi...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has become a global health concern. Various SARS-CoV-2 vaccines have been developed and are being used for vaccination worldwide. However, no therapeutic agents against disease 2019 (COVID-19) so far; therefore, new urgently needed. In the present study, we evaluated several hepatitis C virus direct-acting antivirals as p...

New direct acting antivirals (DAAs) such as daclatasvir (DCV; BMS-790052), which target NS5A function with picomolar potency, are showing promise in clinical trials. The exact nature of how these compounds have an inhibitory effect on HCV is unknown; however, major resistance mutations appear in the N-terminal region of NS5A that include the amphipathic helix and domain 1. The dimeric symmetry ...

Oral direct-acting antivirals (DAAs) are the main therapy for hepatitis C virus (HCV)-associated liver disease in Japan. Daclatasvir/asunaprevir is the first agent and sofosbuvir/ledipasvir is the secondary agent for HCV genotype 1b. More recently, ombitasvir/paritaprevir/ritonavir is also recommended as a potent therapy for HCV genotype 1b. Among the adverse events associated with these oral D...

BACKGROUND The combination of sofosbuvir and daclatasvir is a potent, pangenotypic regimen suitable for mass-scale hepatitis C treatment, especially in resource-limited countries where newer, expensive combinations are not available. This has been widely tested on genotype 4. However, Phase III trials this other genotypes have cost prohibitive. With the introduction generic, low-cost daclatasvi...

Abstract Purpose This study aims to evaluate the effect of oral (sofosbuvir / daclatasvir) Combination on macular and choroidal thickness Egyptian patients with chronic hepatitis C virus infection using Optical Coherence Tomography (OCT) Methods was conducted 30 subjects recruited from Viral Hepatitis Treatment Research Centre examined at Ophthalmology Out Patients Clinics, Ain Shams University...

BACKGROUND cerebrovascular disease (CVD) during childhood is a rare condition; its short, medium and long-term characteristics deserve further investigation. The application of behavioral techniques may improve clinical characterization, thus rendering more efficient therapeutic planning and control. AIM to describe the audiological manifestations in a child with CVD in two distinct moments o...