نتایج جستجو برای: d49
تعداد نتایج: 72 فیلتر نتایج به سال:
Snake venom proteins show high levels of variation at the level of the individual yet the environmental and molecular mechanisms that generate this diversity remain unclear. Here we report the results of a controlled feeding experiment combined with proteomic analyses of periodically collected venom samples to assess the roles of ontogenetic and diet-related effects on venom composition of capt...
UNLABELLED Here we describe and compare the venomic and antivenomic characteristics of both neonate and adult Prairie Rattlesnake (Crotalus viridis viridis) venoms. Although both neonate and adult venoms contain unique components, similarities among protein family content were seen. Both neonate and adult venoms consisted of myotoxin, bradykinin-potentiating peptide (BPP), phospholipase A2 (PLA...
Entropy maximization to maximum likelihood, constrained jointly by the best available experimental phases and by a sufficiently good envelope, can bring about substantial model-independent map improvement, even at medium (3.1 A) resolution [Xiang, Carter, Bricogne & Gilmore (1993). Acta Cryst. D49, 193-212]. In the crystal structure determination of the Bacillus stearothermophilus tryptophanyl-...
An experimental approach to evaluate the net binding free energy of buried hydrogen bonds and salt bridges is presented. The approach, which involves a modified multiple-mutant cycle protocol, was applied to selected interactions between TEM-1-beta-lactamase and its protein inhibitor, BLIP. The selected interactions (two salt bridges and two hydrogen bonds) all involving BLIP-D49, define a dist...
BACKGROUND Primaquine is used to prevent Plasmodium vivax relapse; however, it is not implemented in many malaria-endemic countries, including Cambodia, for fear of precipitating primaquine-induced acute haemolytic anaemia in patients with glucose-6-phosphate dehydrogenase deficiency (G6PDd). Reluctance to use primaquine is reinforced by a lack of quality safety data. This study was conducted t...
Intestinal mucosal mast cells (IMMCs) are closely apposed to nerves, which is consistent with other evidence suggesting that mast cells are innervated. Recent studies have indicated that coordinated changes in mast cell and nerve densities occur in the gut mucosa, during progressive fibrosis, but there is a lack of experimental evidence to support remodeling of intestinal nerve fibers as part o...
کشمش یکی از مهم‌ترین محصولات ارزآور کشاورزی ایران است و ایران پس از کشورهای ترکیه و آمریکا سومین صادرکنندۀ کشمش جهان است. در این مقاله، با استفاده از شاخص‌های مزیت نسبی صادراتی، مزیت وارداتی، نسبتهای تمرکز و هرفیندال- هیرشمن، به بررسی وضعیت تجاری و ساختار بازار صادراتی و وارداتی محصول کشمش در جهان در دورۀ زمانی 2011-2001 پرداخته می‌شود. براساس نتایج، ساختار بازار صادراتی در این دوره انحصار چند...
Soybean [Glycine max (L.) Merr.] germplasm line N98– 4445A (Reg. no. GP-313, PI 636691) was developed and released in 2002 byUSDA-ARS, in cooperation with the North Carolina Agricultural Research Service. This line has a concentration of oleic acid in the seed oil that is approximately 550 g kg. This is between 340 and 380 g kg greater than commercial soybean varieties and 47 g kg more than the...
A high incidence of HBV-related hepatitis is associated with the use of HBsAg-positive marrow for transplantation, and the high viral load in the donor appears to predispose recipients to the development of HBV-related hepatitis postransplant. Preemptive use of lamivudine has proved to reduce hepatitis B exacerbation in HBsAgpositive recipients of allogeneic HCT. Since 2000, the policy in our m...
Bacteriophage λ protein phosphatase (λPP) with Mn2+ as the activating metal cofactor was studied using phosphatase inhibition kinetics and electron paramagnetic resonance (EPR) spectroscopy. Orthophosphate and the oxoanion analogues orthovanadate, tungstate, molybdate, arsenate, and sulfate were shown to inhibit the phosphomonoesterase activity of λPP, albeit with inhibition constants (Ki) that...
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