By means of the Schechter’s Linking method, we study the existence of 2T -periodic solutions of the non-autonomous fourth-order ordinary differential equation u′′′′ −Au′′ −Bu− Vu(t, u) = 0 where A > 0, B > 0, V (t, u) ∈ C1(R × R,R) is 2T -periodic in t and satisfies either 0 < θV (t, u) ≤ uVu(t, u) with θ > 2, or uVu(t, u) − 2V (t, u) ≥ d3|u| with r ≥ 1.

Four multiparous lactating cows (175 to 220 d in milk) were used in a 4 x 4 Latin square design to assess the effects of four doses (0.0, 0.5, 1.0, 1.5 microg/kg of body weight) of lipopolysaccharide (LPS; Escherichia coli 0111:B4) on circulating concentrations of macrominerals and vitamin D metabolites. Treatments were dissolved in 100 ml of sterile saline and infused intravenously over a peri...

Measurements of 25-hydroxyvita-min D 2 (D2) 1 and 25-hydroxyvita-min D 3 (D3) are used to detect vitamin D deficiency and monitor vitamin D supplementation. Inter-laboratory variation within the same method groups makes it impossible to apply standardized reference intervals or published clinical cutoff values. Laboratories therefore must develop site-specific reference intervals. Advances in t...

Little is known regarding optimal vitamin D status in adult dogs. To date no studies on vitamin D supplementation for improving vitamin D status have been reported for adult dogs. The aims of this study were to identify dogs with low vitamin D status and evaluate an oral dosage of cholecalciferol (D3) for effectiveness in increasing vitamin D status. For this, forty-six privately owned dogs wer...

BACKGROUND We earlier showed that 4-phenylbutyrate (PB) can induce cathelicidin LL-37 expression synergistically with 1,25-dihydroxyvitamin D3 in a lung epithelial cell line. We aimed to evaluate a therapeutic dose of PB alone or in combination with vitamin D3 for induction of LL-37 expression in immune cells and enhancement of antimycobacterial activity in monocyte-derived macrophages (MDM). ...

We present the CHAL336 benchmark set-the most comprehensive database for assessment of chalcogen-bonding (CB) interactions. After careful selection suitable systems and identification three high-level reference methods, set comprises 336 dimers each consisting up to 49 atoms covers both σ- π-hole interactions across four categories: chalcogen-chalcogen, chalcogen-π, chalcogen-halogen, chalcogen...

The effect of supplementing diets with various levels of vitamin D3 to provide 0, 0.5, 1, and 5 million IU/(steer x d) for 8 d before slaughter on the mineral content and localization of Ca in LM and muscle fragments was studied during the postmortem aging process. Twelve feedlot steers of three biological types were given access to the four levels of vitamin D for 8 d before slaughter. Differe...

CONTEXT Human growth hormone receptor (GHR) transcripts have two isoforms, full-length (GHRfl) or exon 3 deleted (GHRd3). An association of these isoforms has been found with small for gestational age (SGA) infants but does not influence adult height. The role of this polymorphism in the birth size spectrum in the general population is unclear. OBJECTIVE To determine the association of matern...