The theory of regular cost functions is a quantitative extension to the classical notion of regularity. A cost function associates to each input a non-negative integer value (or infinity), as opposed to languages which only associate to each input the two values “inside” and “outside”. This theory is a continuation of the works on distance automata and similar models. These models of automata h...

Invited for this month's cover is the group of Prof. F. Matthias Bickelhaupt. The cover picture illustrates the authors' quantum chemical finding that π electrons can significantly bend otherwise linear d(10)-ML2 complexes through backbonding. For more details, see the Full Paper on p. 106 ff.

Background: Telomeric DNA is found at the end of eukaryotic chromosomes, where they play a role in protecting chromosome and integrity genome organism through activity telomerase. Saccharomyces cerevisiae exists two genotypes: haploid diploid. Temperature sensitive point mutation on cdc13 gene each genotype deletion exo1 (cdc13-1Exo1 mutants) give rise to mutant survivors enhanced temperatures...

The initial microflora of minimally processed celery and cabbage packaged under a modified atmosphere was determined. The samples came from the same producer and were sold in a supermarket chain of Santiago, Chile. Although neither E. coli nor Salmonella spp. were detected, initial total plate and Enterobacteriaceae counts were high (= 10(5) cfu/g), not meeting in most cases the specifications ...

We have investigated the molecular geometries of a series of dicoordinated d(10)-transition-metal complexes ML2 (M=Co(-), Rh(-), Ir(-), Ni, Pd, Pt, Cu(+), Ag(+), Au(+); L=NH3, PH3, CO) using relativistic density functional theory (DFT) at ZORA-BLYP/TZ2P. Not all complexes have the expected linear ligand-metal-ligand (L-M-L) angle: this angle varies from 180° to 128.6° as a function of the metal...

(1) Background: the broadcast is an outdated fertilization method with a low fertilizer-utilization rate and environmental problems, which seriously restricts development of agriculture. (2) Methods: Under machine-transplanted rice side-deep (MRSF) mode, five treatments were applied: 0 cm (D0), 5 (D5), 7.5 (D7.5), 10 (D10), comprising four different depths fertilization, no (CK). The yield, acc...

An actinomycete strain, Streptomyces hygroscopicus subsp. ossamyceticus (strain D10) was isolated from Thar Desert soil, Rajasthan during the year 2006 and found to produce a yellow color pigment with antibiotic activity. Crude pigment was produced from strain D10 by solid state fermentation using wheat bran medium followed by extraction with ethyl acetate. The antimicrobial activity of the cru...

We investigated blocking the TGF-β signaling pathway in HCC using two small molecule inhibitors (LY2157299, LY2109761) and a neutralizing humanized antibody (D10) against TGF-βRII. LY2157299 and LY2109761 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2157299 inhibited HCC migration and cell growth independ...

A therapy-dedicated cyclotron was installed in the National Cancer Center Hospital East (NCCHE) at Kashiwa in 1997. Prior to the start of clinical use, we investigated the biological effectiveness of therapeutic proton beams for cell lethality. The proton beams accelerated up to 235 MeV were horizontally extracted from the cyclotron, and scattered by a bar-ridge filter to produce a Spread-Out-B...