introduction and aims: helicobacter pylori commonly is associated with gastritis: but only sometimes it causes clinically significant diseases such as gastric and duodenal ulcer. the development of disease depends on the virulence of the infecting h. pylori strain, the susceptibility of the host, and environment co-factors. the cytotoxin associated protein encoded by caga gene is an important v...

Helicobacter pylori infection is associated with an inflammatory response in the gastric mucosa, ultimately leading to cellular hyperproliferation and malignant transformation. Hitherto, only expression of a single gene, or a limited number of genes, has been investigated in infected patients. cDNA arrays were therefore used to establish the global pattern of gene expression in gastric tissue o...

Haemophilus ducreyi produces a cytotoxin responsible for the killing of cultured human epithelial cells. Cytotoxin-neutralizing antibodies were detected in the majority of sera from patients with culture-proven chancroid, and a significantly higher level of such antibodies in patients than in blood donors was noted both in areas where the disease is endemic and those where it is not. We produce...

An animal lectin purified from loach (Misgurnus anguillicaudatus) eggs induced release of cytotoxin from fresh bone marrow cells from mice, although the other lectins tested, wheat germ agglutinin, concanavalin A, and phytohemagglutinin did not. The cytotoxin released from bone marrow cells was a heat-labile protein with a molecular weight of 70,000. The main cells responsible for release of Mr...

Odontomas are the most common type of odontogenic tumors. They are considered to be developmental anomalies (Hamartomas) rather than true neoplasms. This is a case report of complex composite odontoma in a 14 year old girl, which resulted in failure of eruption of permanent upper right lateral incisor and canine while the contralateral teeth had erupted. A calcified mass was seen in the radiogr...

Cytotoxin release by bone marrow-adherent cells and peritoneal macrophages was transiently augmented by i.p. inoculation of syngeneic tumor cells, but not normal cells. These effects were maximal 24-48 h after tumor transplantation. The cytotoxin released from bone marrow-adherent cells obtained 24 h after tumor inoculation had a molecular weight of about 70,000. Peritoneal macrophages obtained...