Human cytomegalovirus (CMV) is purportedly present in glioblastoma (GBM) while absent from the normal brain, making CMV antigens potentially ideal immunological anti-GBM targets. We recently demonstrated that patient-derived CMV pp65-specific T cells are capable of recognizing and killing autologous GBM tumor cells. This data supports CMV antigen-directed immunotherapies against GBM.

OBSTETRICS & GYNECOLOGY Background Cytomegalovirus Cytomegalovirus is a ubiquitous double-stranded DNA herpesvirus that is transmitted by sexual contact or direct contact with infected blood, urine, or saliva. After an incubation period of 28–60 days (mean, 40 days), CMV infection induces immunoglobulin M (IgM) antibody production followed by an immunoglobulin G (IgG) antibody response. Viremia...

Cytomegalovirus (CMV) infection is a relatively late complication of AIDS. Like other viruses contributing to co-morbidity of HIV infection, cytomegalovirus has the propensity to cause multiorgan involvement. We report the case of a 34-year-old seropositive man who presented with bilateral lower limb weakness and symptomatic pallor. He was already on antiretroviral drugs for a month prior to pr...

BACKGROUND Cytomegalovirus (CMV) pneumonitis has been shown to be associated with lymphocytic alveolitis after lung transplantation. In the present study, we investigated a series of bronchoalveolar (BAL) and blood samples, collected in the absence of rejection or acute infectious episodes. in order -1: to evaluate intra-alveolar cell population changes concomitant with CMV replication and -2: ...

A fatal case of neonatal cytomegalovirus (CMV) infection attributed to exchange transfusion is described. The incidence of CMV transmission by exchange and other neonatal transfusion was studied, and the use of CMV antibody-free blood for these procedures was shown to be effective in preventing CMV infection in neonates.

to evaluate the correlation of cytomegalovirus (cmv) and coronary artery disease (cad), one-hundred patients with cad and the same number of healthy individuals as a control group were randomly selected and studied for anti-cmv using elisa method. ninety percent of patients and 77 percent of the control group were anti-cmv positive and statistical analysis showed a significant correlation betwe...

BACKGROUND Cytomegalovirus is highly prevalent virus and usually occurs in immunocompromised patients. The pathophysiology and treatment of inflammatory bowel disease often induce a state of immunosuppression. Because this, there are still doubts and controversies about the relationship between inflammatory bowel disease and cytomegalovirus. AIM Evaluate the frequency of cytomegalovirus in pa...

Cytomegalovirus (CMV) colitis occurs commonly in immunocompromised patients with high mortality. CMV infection has also been reported immunocompetent individuals and it a varied clinical presentation. When HIV-infected are started on antiretroviral therapy (ART) there is reconstitution of the immune system which results paradoxical worsening existing conditions or development new disease known ...

BACKGROUND Congenital cytomegalovirus (CMV) is reported to affect up to 1% of all live births in the United States. T-cell immunity may be important for controlling CMV replication in congenital CMV-infected infants. We describe the natural history of CMV-specific T-cell evolution and CMV replication in infants with congenital CMV infection. METHODS Cytomegalovirus viral load, CMV urine cultu...

conclusion we concluded that cmv is the most common cause of intrauterine infection in infants aged less than 6 months as compared to the healthy ones. we prefer, at least in our country, to consider seropositive (cmv-igm) infants suspected of intrauterine infection (less than 6 months) as congenital form. to arrest the natural progression of congenital cmv, we recommend prolonged course of ora...