Villin is an actin-binding cytoskeletal protein required for brush-border formation in the normal small intestinal and renal proximal tubule epithelium. Villin is a marker of cell differentiation in small intestinal and renal cell lineages, and recent studies have shown villin to be highly expressed in 100% of intestinal-type Barrett's metaplasias. This epithelium is the single greatest risk fa...

BACKGROUND New methods are needed to detect precancerous lesions in lung tissue. We conducted a study to determine the utility of LIFE (laser-induced fluorescence emission) autofluorescence bronchoscopy for the detection of squamous metaplasia and dysplasia in current and former smokers. METHODS In this prospective, single-center study, 53 participants underwent standard white-light bronchosc...

BACKGROUND Esophageal adenocarcinoma develops through a multistage process which is characterized histopathologically by progression from Barrett's intestinal metaplasia to Barrett's esophagus with dysplasia and ultimately to adenocarcinoma. The genetic basis of this process is increasingly well understood, but no studies have examined the role of the transcription factor c-myb in this disease....

The expression of Notch in 30 cases of pleomorphic adenoma was examined by immunohistochemistry. Comparing the results of our study with previous literatures, from the partial CK7 expression and substantial Notch expression in ductal epithelial cells as well as the Notch expression in solid tumor nests, it can be inferred that Notch is involved in cell differentiation. CK13 expression was obser...

Regions where one type of epithelium replaces another (metaplasia) have a predilection for cancer formation. Environmental factors are closely linked to metaplastic carcinogenesis. In particular, cervical cancers associated with human papillomavirus (HPV) infection develop primarily at the transformation zone, a region where metaplastic squamous cells are detected in otherwise columnar epitheli...

Squamous metaplasia ¡sa common abnormality of cellular development and differentiation in the epithelia of many organs, including the prostate gland in humans. Agents known to elevate the level of intracellular cyclic adenine nucleotide have been found to direct various kinds of epithelial cells onto a pathway of epidermoid (squamous) development and a differ entiation marked by keratin produc...

basaloid squamous cell carcinoma of the esophagus are rare [1–4], while esophageal combined carcinoma is very rare [5]. Most cases of combined carcinoma of the esophagus consist of squamous cell carcinoma, adenocarcinoma, and small cell carcinoma [5]. This is the first report of combined adenoid cystic carcinoma, basaloid squamous cell carcinoma, and squamous cell carcinoma of the esophagus. A ...

The importance of cervical squamous metaplasia and human papillomavirus 16 (HPV 16) infection for cervical carcinoma has been well established. Nearly 87% of the intraepithelial neoplasia of the cervix occur in the transformation zone, which is composed of squamous metaplastic cells with unclear origin. HPV DNA, mostly HPV 16, has been found in 90% of cervical carcinomas, but only limited exper...

Squamous metaplasia ¡sa common abnormality of cellular development and differentiation in the epithelia of many organs, including the prostate gland in humans. Agents known to elevate the level of intracellular cyclic adenine nucleotide have been found to direct various kinds of epithelial cells onto a pathway of epidermoid (squamous) development and a differ entiation marked by keratin produc...