Organophosphorus (OP) insecticide self-poisoning is responsible for about one-quarter of global suicides. Treatment focuses on the fact that OP compounds inhibit acetylcholinesterase (AChE); however, AChE-reactivating drugs do not benefit poisoned humans. We therefore studied the role of solvent coformulants in OP toxicity in a novel minipig model of agricultural OP poisoning. Gottingen minipig...

The Baeyer-Villiger oxidation is a key transformation for sustainable chemical synthesis, especially when H2 O2 and solid materials are employed as oxidant and catalyst, respectively. 4-substituted cycloketones, which are readily available from renewables, present excellent platforms for Baeyer-Villiger upgrading. Such substrates exhibit substantially higher levels of activity and produce lacto...

Thiamine deficiency in all species thus far studied affects the metabolism of pyruvic acid. The lacki until quite recently (l), of a rapid specific method for estimating pyruvic acid necessitated the use of the rapid but less specific technique introduced by Clift and Cook (2). Occasionally it has been estimated by isolation as the 2,4-dinitrophenylhydrazone, by the method of Case (3) or a modi...

The trigeminal nerve responds to a wide variety of irritants. Trigeminal nerve fibers express several receptors that respond to chemicals, including TRPV1 (vanilloid) receptors, acid-sensing ion channels, P2X (purinergic) receptors, and nicotinic acetylcholine receptors. In order to assess whether TRPV1 plays a role in responses to a broad array of substances, TRPV1 (along with green fluorescen...

We identified chnR, a gene encoding an AraC-XylS type of transcriptional activator that regulates the expression of chnB, the structural gene for cyclohexanone monooxygenase (CHMO) in Acinetobacter sp. strain NCIMB 9871. The gene sequence of chnE, which encodes an NADP(+)-linked 6-oxohexanoate dehydrogenase, the enzyme catalyzing the fifth step of cyclohexanol degradation, was also determined. ...

A new simple phloroglucinol derivative characterized as 1-(6-hydroxy-2,4-dimethoxyphenyl)-2-methyl-1-propanone (1) was isolated from Hypericum cistifolium (Hypericaceae) as a major constituent of the non-polar plant extract. Minor amounts of this new compound, in addition to two known structurally related phloroglucinol derivatives (2 and 3), and two new terpenoid derivatives characterized, res...

Cr-Si binary oxide prepared by a sol-gel method, when activated by visible light, catalyses highly selective oxidation of cyclohexane to cyclohexanone with molecular oxygen.

Cyclohexanone and cycloheptanone can be enantioselectively functionalized in the 3-position with up to 92% ee and 87% ee, respectively, by the base-promoted dimerization of the corresponding enones using 3,4,5-tribenzyloxybenzyl cinchoninium bromide, as a new effective catalyst.

2-Alkyl cycloketones are essential chemicals and intermediates for synthetic perfumes pesticides, which conventionally produced by multistep process including aldol condensation, separation hydrogenation. In present work, a batch one-pot cascade approach using aldehydes as the raw materials, bifunctional Pd/ZrO2 catalyst was developed synthesis of 2-alkyl cycloketones, e.g., cyclohexanone cyclo...

Catalytic hydrogenation of nitrocyclohexane proved to be an attractive alternative source various chemical compounds: cyclohexanone oxime, cyclohexanone, cyclohexanol, cyclohexylamine and dicyclohexylamine. A growing interest in this reaction has been observed the last few years. Herein, we present catalytic performance Cu/SiO2, Co/SiO2 CuCo/SiO2 gas liquid flow hydrogenation. The analysis synt...