Stimuli such as u.v. light or trauma which induce recurrence of herpes simplex may act by affecting virus replication in the skin. Such stimuli release pharmacologically active agents in the skin, including prostaglandins (PGs) such as PGE2. These agents, and other compounds which alter levels of adenosine cyclic monophosphate (cyclic AMP), were tested for their effect on the replication of her...

Acetyl CoA carboxylase was purified from liver of fasted-refed rats to near homogeneity, based on electrophoretic analysis and biotin content. These preparations contained an endogenous protein kinase that catalyzed the transfer of radioactive phosphate from [gamma-32P]ATP to acetyl CoA carboxylase, accompanied by a decrease in acetyl CoA carboxylase activity. Phosphate incorporated into acetyl...

Certain polypeptide hormones and catecholamines act to stimulate adenyl cyclase and then increase the formation of adenosine 3',5'-cyclic monophosphate (cyclic AMP). Cyclic AMP activates protein kinases which in turn affect the activities of certain enzymes and properties of some proteins. This process is thought to be important as a mechanism of hormone actions. The localization of adenyl cycl...

In the title salt, C(12)H(11)N(2)O(2) (+)·C(7)H(4)NO(5) (-), the cations and anions inter-act through asymmetric cyclic pyridinium-carboxyl-ate N-H⋯O,O' hydrogen-bonding associations [graph set R(1) (2)(4)], giving discrete heterodimers having weak cation-anion π-π aromatic ring inter-actions [minimum ring centroid separation = 3.7116 (9) Å].

Let G be a complete Kac–Moody group of rank n ≥ 2 such that the Weyl group of G is a free product of cyclic groups of order 2. We construct new families of examples of cocompact lattices in G, many of which act transitively on the chambers of the building for G.

Background The cGMP-dependent protein kinase (PKG) has two tandem cyclic nucleotide binding (CNB) domains which act as the primary intracellular receptor for cGMP [1,2]. PKG exhibits a homodimeric rod-like structure which undergoes significant molecular rearrangements upon the binding of cGMP [3-5]. However, a detailed structural analysis of the core regulatory elements inherent to PKG is still...

The role of parasites in regulating populations has been the subject of debate. We tested whether parasites caused population cycles in red grouse by manipulating parasite intensities in four, paired 1 km(2) study areas during cyclic population declines over 4 years. Parasite reductions led to (1) larger grouse broods, (2) higher population densities in both autumn and spring, (3) reduced autum...

A classification system is presented to distinguish 3 corn nucleases-Ribonuclease I, Ribonuclease II, and Nuclease I-which were described in the first paper of this series. The 2 ribonucleases are specific for RNA, are endonucleases, and liberate purine and pyrimidine cyclic nucleotides from dinucleotide monophosphates as well as from RNA. Ribonuclease I and II hydrolyze the purine cyclic nucle...

Treatment of Chinese hamster ovary cells in vitro with dibutyrl adenosine cyclic 3':5'-monophosphate converts the culture from one of compact, randomly oriented cells that grow in multilayers to a monolayer of elongated, fibroblast-like cells growing parallel to one another. Testosterone propionate, which has a similar though smaller effect at high concentrations and after prolonged incubation,...

The mol-ecular structure of the title compound, C10H12O4, contains an intra-molecular hydrogen bond between the phenol and acetyl substituents. In the crystal, C-H⋯π inter-actions act between the mol-ecules in a cyclic manner to stabilize stacks of mol-ecules along the b axis. Several C-H⋯O inter-actions are present between the stacks.