نتایج جستجو برای: cyanex 302

تعداد نتایج: 6187  

Journal: :Debate Feminista 2001

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Journal: :Molecular cancer therapeutics 2012
Fanying Meng James W Evans Deepthi Bhupathi Monica Banica Leslie Lan Gustavo Lorente Jian-Xin Duan Xiaohong Cai Alexandra M Mowday Christopher P Guise Andrej Maroz Robert F Anderson Adam V Patterson Gregory C Stachelek Peter M Glazer Mark D Matteucci Charles P Hart

TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard currently undergoing clinical evaluation. Here, we describe broad-spectrum activity, hypoxia-selective activation, and mechanism of action of TH-302. The concentration and time dependence of TH-302 activation was examined as a function of oxygen concentration, with reference to the prototypi...

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2012
Fanying Meng James W. Evans Deepthi Bhupathi Monica Banica Leslie Lan Gustavo Lorente Jian-Xin Duan Xiaohong Cai Alexandra M. Mowday Christopher P. Guise Andrej Maroz Robert F. Anderson Adam V. Patterson Gregory C. Stachelek Peter M. Glazer Mark D. Matteucci Charles P. Hart

TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard currently undergoing clinical evaluation. Here, we describe broad-spectrum activity, hypoxiaselective activation, and mechanism of action of TH-302. The concentration and time dependence of TH-302 activation was examined as a function of oxygen concentration, with reference to the prototypic...

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2005
Jaakko Heikkilä Jukka Peltola

Changes in climatic and policy environments combined with uncertainty related to stochastic environmental fluctuations make design of invasive pest policy challenging. These external changes are often exacerbated by changes in the species characteristics. We discuss facing local change and uncertainty when deciding ex ante on a specific policy strategy. Our empirical case deals with an invasive...

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Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Jessica D Sun Qian Liu Jingli Wang Dharmendra Ahluwalia Damien Ferraro Yan Wang Jian-Xin Duan W Steve Ammons John G Curd Mark D Matteucci Charles P Hart

PURPOSE Tumor hypoxia underlies treatment failure and yields a more aggressive, invasive, and metastatic cancer phenotype. TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM). The purpose of this study is to characterize the antitumor activity of TH-302 and investigate its selective targeting of the hypoxic cells in human tum...

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2015
Mahmoud-Reza Rafiee Afsaneh Malekzadeh Shafaroudi Sara Rohban Hamid Khayatzadeh Hamid Reza Kalhor Seyed Javad Mowla

OBJECTIVE MiR-302-367 is a cluster of polycistronic microRNAs that are exclusively expressed in embryonic stem (ES) cells. The miR-302-367 promoter is functional during embryonic development but is turned off in later stages. Motivated by the cancer stem cell hypothesis, we explored the potential expression of miR-302 in brain tumor cell lines. MATERIALS AND METHODS In the present experimenta...

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2015
Zhonghui Zhang Yuanfan Hong Di Xiang Pei Zhu Elise Wu Wen Li Jeffrey Mosenson Wen-Shu Wu

miR-302/367 is the most abundant miRNA cluster in human embryonic stem cells (hESCs) and can promote somatic cell reprogramming. However, its role in hESCs remains poorly understood. Here, we studied functional roles of the endogenous miR-302/367 cluster in hESCs by employing specific TALE-based transcriptional repressors. We revealed that miR-302/367 cluster dually regulates hESC cell cycle an...

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2013
Sergio Jiménez Claudia Jeanneth Becerra Alexander F. Gelbukh

In this paper we describe our system used to participate in the Student-Response-Analysis task-7 at SemEval 2013. This system is based on text overlap through the soft cardinality and a new mechanism for weight propagation. Although there are several official performance measures, taking into account the overall accuracy throughout the two availabe data sets (Beetle and SciEntsBank), our system...

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2003
Sheela Patel Kalpana Sharma

When organisations commit themselves to work with urban poor communities, they are often faced with difficult choices. Should they confront and challenge the powers that determine and rule their lives or should they work around the problem and negotiate? What do they need themselves to be in a position of strength, should they choose the latter path? Can their interests be served if they choose...

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2015
KE - FENG WANG HANG YANG WEN - QI JIANG SU LI YU - CHEN CAI

There are numerous studies that demonstrate the anti-neoplastic activity of phosphatidylinositol 3-kinase (PI3K) inhibitors and the mechanisms of inducing autophagy in cancer cells. The new anticancer drug puquitinib mesylate (XC-302) is a molecular-targeted drug, which suppresses the activity of PI3K directly. However, it remains unclear whether XC-302 can develop an antitumor effect by induci...

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  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->