Background: Due to its extensive arsenal of virulence factors and inherent resistance to antibiotics, Pseudomonas aeruginosa is a threat particularly in immunocompromised patients. Considering the central role of quorum sensing in the production of virulence factors, inhibition of bacterial communication mechanism constitute an opportunity to attenuate pathogenicity of bacteria resistant to ava...

background and objectives: this study was designed to evaluate the activity of quercus infectoria galls extract (qifge) on virulence factor production and inhibition of quorum sensing (qs) in pseudomonas aeruginosa. materials and methods: minimum inhibitory concentration (mic) of qifge against 5 strains of p. aeruginosa was determined. the extract at sub-mic was used to determine biofilm format...

pectobacterium carotovorum is one of the most important bacterial pathogens of potato in the world.the expression of numerous genes including those involved in the production of virulence determinants in this bacterium are regulated by quorum sensing (qs). the signal molecules involved in qs in p. carotovorum belong to the group of n-acyl homoserine lactones (ahls). recently, several soil bacte...

the occurrence of antibiotic-resistant pathogenic bacteria is becoming a serious problem. the rise of multiresistance strains has forced the pharmaceutical industry to come up with new generation of more effective and potent antibiotics, therefore creating development of antivirulence compounds. due to extensive usage of cell-to-cell bacterial communication (qs) systems to monitor the productio...

Quorum sensing control mediated by N-acyl homoserine lactone (AHL) signaling molecules has been established as a key feature of the regulation of exoenzyme production in many gram-negative bacteria. In Chromobacterium violaceum ATCC 31532 a number of phenotypic characteristics, including production of the purple pigment violacein, hydrogen cyanide, antibiotics, and exoproteases are known to be ...

Aims: Our proposal aimed to evaluate Acyl Homoserine Lactones (AHL) as a functional marker for Multi drug resistant (MDR) potential in clinical isolates of Acinetobacter baumannii. We investigated the AHL production using biosensor assay directly on commonly used agar media.
 Place and Duration Study: Department Molecular Diagnostics Biomarkers, Gleneagles Global Hospitals, Lakdikapul, Hyd...

Pseudomonas aeruginosa plays a major role in many chronic infections. Its ability to readily form biofilms contributes to its success as an opportunistic pathogen and its resistance/tolerance to antimicrobial/antibiotic therapy. A low molecular weight alginate oligomer (OligoG CF-5/20), derived from marine algae, has previously been shown to impair motility in P. aeruginosa biofilms and disrupt...