Severe cutaneous adverse drug reaction (SCAR) is considered to be a multifactorial drug side effect. This study was designed to investigate the epidemiology and human leukocyte antigen (HLA)-A and -B gene polymorphisms in pediatric patients with SCAR admitted in tertiary referral center, southwestern of Iran from 2013 to 2017. Demographic data, past allergy and autoimmune history, clinical pres...

1. Pudukadan D, Thappa DM. Adverse cutaneous drug reactions: Clinical patterns and causative agents in a tertiary care center in South India. Indian J Dermatol Venereol Leprol 2004;70:20– 4. 2. Shear NH, Knowles SR, Sullivan JR, Shapiro L. Cutaneous reactions to drugs. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, et al, editors. Fitzpatrick‘s Dermatology in general med...

Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe cutaneous drug adverse reaction (SCAR) with a not well known pathogenesis. Strong genetic associations between HLA groups and drug allergy have been reported but seem to be specific for a type of SCAR, one drug and an ethnic group. Using a pangenomic approach, effective even on a small effective, by an...

OBJECTIVE Cutaneous reactions are among the most common adverse reactions to drugs. The purpose of this study is to examine the aetiology and outcome of cutaneous drug reactions among patients admitted to the Dermatology Ward at the University Hospital of the West Indies. SUBJECTS AND METHODS This was a retrospective study looking at all patients who were admitted with a diagnosis of a cutane...

Sir, Chemotherapy-induced acral erythema (CIAE) is a cytotoxic drug reaction to certain systemic chemotherapeutic agents, such as £uorouracil, doxorubicin, and especially cytosine arabinoside (1). Following discontinuation of chemotherapy, cutaneous lesions subside in 1 ^ 2 weeks with eventual desquamation. Rechallenge of patients with similar chemotherapeutic agents has reproduced the reaction...

Background Acute generalized exanthematous pustulosis (AGEP) is rare cutaneous drug reaction involving drug-specific T lymphocytes and neutrophilic inflammation. Imatinib is a tyrosine kinase inhibitor used widely in treatment of chronic myeloid leukemia (CML). Rash is a common side effect of imatinib, occurring in up to 30% of patients. However, there are only two case reports to date describi...

BACKGROUND Previous studies have shown that calcium channel blockers can cause cutaneous adverse reactions; however, the amounts of data collected are limited. Recently, there have been new drugs available for which only a few reports have been published with regard to cutaneous adverse reactions. OBJECTIVE The purpose of our study was to estimate the rate and to study clinical patterns of cu...

Background Little is known on the short-term or medium-term psychological and psychiatric sequelae following Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). Based on this we did a prospective study designed to assess anxiety and depression in patients with severe cutaneous adverse drug reactions by indicating hi...

INTRODUCTION According to studies conducted in outpatients, it is estimated that 2.5% of children who are treated with a drug will experience a cutaneous adverse drug reaction (CADR). AIM To analyze the CADR reports involving pediatric patients recorded by three different university hospitals for describing common, serious, and interesting cutaneous drug eruption patterns. MATERIAL AND METH...

DTH: delayed hypersensitivity IV: intravenous RCM: radio contrast media SDRIFE: systemic drug-related intertriginous and flexural exanthema INTRODUCTION Systemic drug-related intertriginous and flexural exanthema (SDRIFE) is a cutaneous reaction, characterized by 5 diagnostic criteria (Table I). We report on 3 patients with SDRIFE induced by radio contrast media (RCM) and describe the dermatolo...