Curcumin is a polyphenolic pigment isolated from the rhizomes of Curcuma longa (turmeric), a medicinal plant widely used in the ancient Indian and Chinese medicine. The antiplasmodial activity of curcumin is often hampered by its fast metabolism and poor water solubility, thus its incorporation into a delivery system could circumvent this problem. This study aimed to evaluate the in vivo antipl...

Curcumin is a polyphenolic compound, derived from Curcuma longa, and it has several pharmacological effects such as antioxidant, anti-inflammatory, antitumor. Although pleiotropic molecule, curcumin’s free form, which lipophilic, low bioavailability rapidly metabolized, limiting its clinical use. With the advances in techniques for loading curcumin into nanostructures, possible to improve exten...

Retinoblastoma is the most common intraocular tumor in children. Malfunctioning of many signaling pathways regulating cell survival or apoptosis, make the disease more vulnerable. Notably, resistance to chemotherapy mediated by MRP-1, lung-resistance protein (LRP) is the most challenging aspect to treat this disease. Presently, much attention has been given to the recently developed anticancer ...

Using current methodologies, drug delivery to small airways, terminal bronchioles, and alveoli (deep lung) is inefficient, especially to the lower lungs. Urgent lung pathologies such as acute respiratory distress syndrome (ARDS) and post-lung transplantation complications are difficult to treat, in part due to the methodological limitations in targeting the deep lung with high efficiency drug d...

BACKGROUND The natural compound curcumin (Cur) can regulate growth inhibition and apoptosis in various cancer cell lines, although its clinical applications are restricted by extreme water insolubility and instability. To overcome these hurdles, we fabricated a Cur-coordinated reactive oxygen species (ROS)-responsive nanoparticle using the interaction between boronic acid and Cur. MATERIALS A...

Since time immemorial, natural products have found applications for the treatment of many maladies and ailments. This review attempts to portray chemistry, bio-medical activities efficacy in therapy COVID-19 one age-old famous spice cumin an eminent herb turmeric. Both them significant disciplines Ayurveda their physiological nutraceutical benefits. It is worth mentioning that versatility turme...

Abstract Background Here, we examined the tumoricidal effect of Gemini surfactant nanoparticles enriched with curcumin on 3D spheroid HT-29 cells. The delivery and other phytocompounds to tumor niche is an important challenge. Methods Spheroid cells were generated by using a conventional hanging drop method exposed different concentrations Gemini-curcumin nanoparticles. changes in integrity cel...