Presence of cardiac dysfunction has been associated with an unfavorable prognosis in patients with liver cirrhosis. In the present study, 92 consecutive, newly-diagnosed patients with liver cirrhosis were prospectively evaluated. Liver disease was graded according to the modified Child-Turcotte-Pugh (CTP) score whereas left ventricular diastolic function was assessed by Doppler-echocardiography...

Abstract Cloud radiative kernels (CRK) built with transfer models have been widely used to analyze the cloud effect on top of atmosphere (TOA) fluxes, and it is expected that CRKs would also be useful in analyses surface which determines regional temperature change variability. In this study, at TOA were using Rapid Radiative Transfer Model (RRTM). Longwave (CRE) primarily driven by base proper...

The Canadian traveler problem (CTP) is the problem of traversing a given graph, where some of the edges may be blocked – a state which is revealed only upon reaching an incident vertex. Originally stated by Papadimitriou and Yannakakis (1991), the adversarial version of CTP was shown to be PSPACE-complete, with the stochastic version shown to be #P-hard. We show that stochastic CTP is also PSPA...

conclusions in conclusion, ctp-hbcag18-27-tapasin could reduce apoptosis of cd8+ t cells, increase the percentages of ifn-γ+ cd8α+ t cells, and elicit cell-mediated immunity in hla-a2 transgenic mice; these processes were associated with activation of the pi3k/akt signaling pathway. results the results showed that ctp-hbcag18-27-tapasin significantly increased the percentages of ifn-γ+ cd8α+ t ...

CTP synthase is encoded by the pyrG gene and catalyzes the conversion of UTP to CTP. A Lactococcus lactis pyrG mutant with a cytidine requirement was constructed, in which beta-galactosidase activity in a pyrG-lacLM transcriptional fusion was used to monitor gene expression of pyrG. A 10-fold decrease in the CTP pool induced by cytidine limitation was found to immediately increase expression of...

The Saccharomyces cerevisiae URA7-encoded CTP synthetase is phosphorylated and stimulated by protein kinases A and C. Previous studies have revealed that Ser is the target site for protein kinase A. Using a purified S424A mutant CTP synthetase enzyme, we examined the effect of Ser phosphorylation on protein kinase C phosphorylation. The S424A mutation in CTP synthetase caused a 50% decrease in ...

The Saccharomyces cerevisiae URA7-encoded CTP synthetase is phosphorylated and stimulated by protein kinases A and C. Previous studies have revealed that Ser424 is the target site for protein kinase A. Using a purified S424A mutant CTP synthetase enzyme, we examined the effect of Ser424 phosphorylation on protein kinase C phosphorylation. The S424A mutation in CTP synthetase caused a 50% decrea...

The effects of cortical tissue preparations (CTP) from human brain on the production of reactive oxygen species (ROS) has been investigated with several biochemical model reactions. As indicators for ROS, fragmentation of the methionine derivatives, alpha-keto-gamma-methylthiobutyric acid (KMB) or 1-amino-cyclopropane-1-carboxylic acid (ACC), yielding ethene have been used. With these systems w...

The aim of this study was to determine the value of computed tomography perfusion (CTP) parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time-to-peak (TP), in a clinical study of patients with stroke. Additionally, we determined which parameter or combination of parameters are reliable in detecting the presence of an infarct and penumbra....

BACKGROUND Despite its increasing prevalence and acceptance among the general public, cannabis use continues to be viewed as an aberrant activity in many contexts. However, little is known about how stigma associated with cannabis use affects individuals who use cannabis for therapeutic purposes (CTP) and what strategies these individuals employ to manage associated stigma. The aim of this Cana...