The binding of basic fibroblast growth factor (FGF-2) to its cell surface receptor (CSR) and subsequent signal transduction is known to be enhanced by heparan sulfate proteoglycans (HSPGs). HSPGs bind FGF-2 with low affinity and likely impact CSR-mediated signaling via stabilization of FGF-2-CSR complexes via association with both the ligand and the receptor. What is unknown is whether HSPG ass...

Purpose – The paper aims to present a conceptual framework for analysing CSR practices in global supply chains. It also seeks to demonstrate how a pioneering Swedish company, IKEA, implements and manages CSR practices at its suppliers. Design/methodology/approach – A case analysis of IKEA illustrates the implementation and management of CSR practices in supply chains. The focus is on internal a...

This paper argues that CSR, as a business, governance and ethics system, has failed. This assumes that success or failure is measured in terms of the net impact (positive or negative) of business on society and the environment. The paper contends that a different kind of CSR is needed if we are to reverse the current direction of many of the world’s most pressing social, environmental and ethic...

As a champion of small RNA research for two decades, Caenorhabditis elegans has revealed the essential Argonaute CSR-1 to play key nuclear roles in modulating chromatin, chromosome segregation and germline gene expression via 22G-small RNAs. Despite CSR-1 being preserved among diverse nematodes, the conservation and divergence in function of the targets of small RNA pathways remains poorly reso...

Coherent synchrotron radiation (CSR) effects play an important role in accelerator physics. CSR effects can be negative (emittance growth in bunch compressors and microbunching instability) or positive (production of CSR in a controlled way). Moreover, CSR is of interest in other fields such as astrophysics. Only a few simple models have been solved analytically. This motivates the development ...

Corporate social responsibility (CSR) research is not new, but its importance to today's socially conscious market environment is even more evident in recent years. This study moves beyond CSR as simply the socially responsible actions and policies of organizations and focuses on the complex psychology of CSR as it relates to individuals within the organization. Given CSR can positively affect ...

BACKGROUND Immunoglobulin class-switch recombination defects (CSR-D) are rare primary immunodeficiencies characterized by impaired production of switched immunoglobulin isotypes and normal or elevated IgM levels. They are caused by impaired T:B cooperation or intrinsic B cell defects. However, many immunoglobulin CSR-Ds are still undefined at the molecular level. OBJECTIVE This study's object...

In the absence of core nonhomologous end-joining (NHEJ) factors, Ab gene class-switch recombination (CSR) uses an alternative end-joining (A-EJ) pathway to recombine switch (S) region DNA breaks. Previous reports showing decreased S-junction microhomologies in MSH2-deficient mice and an exonuclease 1 (EXO1) role in yeast microhomology-mediated end joining suggest that mismatch repair (MMR) prot...

C social responsibility (CSR) has emerged as a signifi cant subject of public policy, in many countries as well as internationally. Considered by some to be “the business issue for the twenty-fi rst century”, CSR is assuming an increasing part of the larger debates over both globalization and sustainable development. There is no universally agreed defi nition of CSR. Differing perceptions of CS...

An agent-based model of firms and their stakeholders' economic actions was used to test the theoretical feasibility of sustainable corporate social responsibility activities. Corporate social responsibility has become important to many firms, but CSR activities tend to get less attention during busts than during boom times. The hypothesis tested is that the CSR activities of a firm are more eco...