More than 60.000 hip arthroplasty are performed every year in Italy. Although Ultra-High-Molecular-Weight-Polyethylene remains the most used material as acetabular cup, wear of this material induces over time in vivo a foreign-body response and consequently osteolysis, pain, and the need of implant revision. Furthermore, oxidative wear of the polyethylene provoke several and severe failures. To...

Introduction: Wear of ultra-high molecular weight polyethylene (UHMWPE) is a major factor that affects longevity of the total joint replacement. In total hips (THR), cross-linking of polyethylene has been shown to be highly effective in reducing wear both clinically and experimentally [1-3]. Also, in TKR, Schmidig et al. [4] showed a 90% reduction of wear rate in 10 Mrad compared to 3 Mrad tibi...

lidocaine (lc) is a local anesthetic agent. the aim of this study was to prolong the anesthetic effect of this drug in the oral cavity in the treatment of oral mucositis. films of lc were prepared with three different molecular weights (mw) of chitosan in three different concentrations (1-3%) and were then cross-linked by solvent casting evaporation method with tripolyphosphate penta sodium sal...

Polyethylene wear is a great concern in total joint replacement. It is now considered a major limiting factor to the long life of such prostheses. Cross-linking has been introduced to reduce the wear of ultra-high-molecular-weight polyethylene (UHMWPE). Computational models have been used extensively for wear prediction and optimization of artificial knee designs. However, in order to be indepe...

The long-term durability of polyethylene lining total hip arthroplasty (THA) mainly depends on periprosthetic osteolysis due to wear particles, especially in young active patients. In hip simulator study, reports revealed significant wear reduction of the alumina ceramic-on-polyethylene articulation of THA compared with metal-on-polyethylene bearing surfaces. However, medium to long-term clinic...

INTRODUCTION: Polyethylene wear particles induce cytokine release by macrophage, which leads to osteolysis and aseptic loosening in total joint arthroplasties. Generation of polyethylene wear particles is one of the most important factors that affecting mid-term and long-term results of total hip arthroplasty (THA). Therefore, to reduce wear generation and to achieve better long-term results of...

INTRODUCTION: Polyethylene wear particles induce cytokine release by macrophage, which leads to osteolysis and aseptic loosening in total joint arthroplasties. Generation of polyethylene wear particles is one of the most important factors that affecting mid-term and long-term results of total hip arthroplasty (THA). Therefore, to reduce wear generation and to achieve better long-term results of...

Advancements in knee replacement design, material and sterilisation processes have provided improved clinical results. However, surface wear of the polyethylene leading to osteolysis is still considered the longer-term risk factor. Experimental wear simulation is an established method for evaluating the wear performance of total joint replacements. The aim of this study was to investigate the i...

in this study, modified starch was used as a fat replacer in the milk. the fat replacer was manufactured from modified starch such as pre-gelatinized and cross–linked starches. modified starches were manufactured by hydrochloric acid and citric acid treatments from potato and wheat and were added to skim milk at concentrations of 0.15%, 0.30% and 0.45%. viscosity, total solid, fat content, titr...