Although activity that induced tumor regression was observed and termed tumor necrosis factor (TNF) as early as the 1960s, the true identity of TNF was not clear until 1984, when Aggarwal and coworkers reported, for the first time, the isolation of 2 cytotoxic factors: one, derived from macrophages (molecular mass 17 kDa), was named TNF, and the second, derived from lymphocytes (20 kDa), was na...

BACKGROUND: Crohns disease is an incurable progressive condition of the gastrointestinal tract in which up to 90% patients undergo one or more surgical interventions during their lifetime. Despite active development and implementation new techniques for treatment disease, incidence postoperative complications remains high, i.e., 25%30%. Until now, influence various factors on outcomes choice di...

Abstract Background Adequate scoring of endoscopic recurrence in Crohn’s disease patients is utmost importance, as it used to diagnose recurrent disease, predict outcomes, (re-)initiate or change therapy and monitor its effect. This study aims assess the variance after ileocolic resection for Crohn's using most common classification systems, Rutgeerts (RS) modified (mRS) classification. Methods...

In this paper we compare the social network structure of people talking about Crohn’s disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn’s community’s contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community’s communication network structure is most cohesive. INTRODUCTION Social media has become a ma...

Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease (IBD). The pathogenesis of IBD is complex and so far not fully understood. The long-term clinical outcome of UC is hard to predict. Some clinical phenotypes of UC may to some extent predict the severity of the disease, but the clinical impact of these predictors is minor. . The new immunomolecular understanding of the pat...