AIM To define sensitive and reliable Doppler parameters for measurements in the superior mesenteric artery and mural arteries of affected bowel loops used in the assessment of Crohn disease activity. METHODS We performed cross-sectional study at a tertiary care setting in Zagreb, Croatia, between January 2001 and March 2005. We measured arterial flow in the superior mesenteric artery and affe...

A small number of cases of Crohn disease associated with myelodysplastic syndromes or leukemia have been reported in adults in the last 25 years in the English-language medical literature. The authors report a case of a 9-year-old boy who developed Crohn disease and myelodysplastic syndrome concurrently. Analysis of his bone marrow showed a chromosome 20 abnormality. Although chromosome 20 abno...

Infliximab is one of the most widely used tumour necrosis factor-alpha (TNF) inhibitors for control of Crohn disease. We report the case of a patient with ileocolonic Crohn disease developing major arterial thrombosis after treatment with infliximab. After conservative management and infliximab withdrawal, thrombus dissolution and vessel recannalisation were observed. Few cases of arterial thro...

This Is a Story about Controls Unraveling the pathogenesis of a complex disease is daunting. Variation in multiple genes and multiple environmental factors could be at play, as could variation in the interactions of these risk factors with each other. Lest you despair, Cadwell et al. prove that it is possible to reveal features of the disease process through a careful set of experiments with go...

SUMMARY It is proposed that Regional Enteritis, commonly called Crohn's Disease should properly be named Crohn-Dalziel disease.

Purpose To describe a case of Crohn disease presenting as occlusive vasculitis resulting in a central retinal artery occlusion (CRAO) in one eye and transient ischemic optic neuropathy in the fellow eye. Observations An 18-year-old patient recently diagnosed with biopsy-proven Crohn disease presented with CRAO OD after a previous episode of transient visual loss OS. Extensive workup was negat...

INTRODUCTION AND OBJECTIVE Patient preferences with respect to available therapies must be taken into account if the quality of care of patients with Crohn´s disease is to be improved. The objective was to develop the IMPLICA preferences questionnaire for Crohn´s disease patients treated with biological therapies. METHODS As per standard methodology, the questionnaire was developed in Spanish...

Crohn disease often recurs after surgical resection. Despite extensive research in the prevention of postoperative Crohn disease, optimal management strategies have yet to be defined. Risk of disease recurrence needs to be carefully balanced against potential risks associated with treatment. Patients with low risk of postoperative recurrence may not require medication, whereas those at moderate...

Inflammatory bowel disease is a chronic inflammatory condition of the gastrointestinal tract that manifests as ulcerative colitis and Crohn disease. Both these clinical entities result from interrelated genetic and environmental factors that may be channeled through an abnormality in mucosal immune function, possibly due to dysregulated or excessive T helper cell (T(H))1 (Crohn disease) or T(H)...

Crohn’s disease is a chronic inflammatory condition that can affect any segment of the gastrointestinal tract from the oral cavity to the anus. The disease often manifests with varied symptoms and numerous potential complications that include intestinal strictures, enteric fistulas, intaabdominal abscesses, and gastrointestinal hemorrhage. Patients with Crohn’s disease are a heterogeneous group...