Background: Rotenone is one of the most widely used pesticides in agriculture and may affect public health through food chain. A possible mechanism rotenone toxicity oxidative stress. This study, supportive effect crocin (a substance derived from saffron) as an antioxidant on renal experimental animal model was investigated. Methods: First, male rats were divided into 4 groups (6 each group) re...

Crocus sativus L. (C. sativus), commonly known as saffron, is used as a food additive, preservative and medicinal herb. It has been considered as an alternative treatment for gastrointestinal diseases. C. sativus’ medicinal effects are associated to its major ingredients including crocin, crocetin and safranal. This study found that the gastrointestinal effects of C. sativus and its major ingre...

Crocus sativus L. (C. sativus), commonly known as saffron, is used as a food additive, preservative and medicinal herb. It has been considered as an alternative treatment for cardiovascular diseases. C. sativus’ medicinal effects are associated to its major ingredients including crocin, crocetin and safranal. This study found that the cardiovascular effects of C. sativus and its major ingredien...

This study was designed to investigate the therapeutic effects of saffron (Crocus Sativus L) and its main constituent crocin on neuropathic pain behavioral responses induced by chronic constriction injury (CCI) in rats. Adult male Wistar rats (200 to 250 g) were randomly assigned into 5 groups: Sham + saline, CCI + saline, CCI+ saffron (30 mg/kg), CCI +crocin (15 mg/kg) and CCI + crocin (30 mg/...

Crocins in commercial liquid saffron extracts (Saffr’activ®) were identified using high-performance chromatography (HPLC) with a diode array detector (DAD) and mass spectrometry (MS). The impact of storage on the qualities extract studied HPLC-DAD-MS by exposing trans-4-GG crocin to environmental factors. Light temperature induced degradation after only one week. Trans-4-GG was totally hydrolyz...

BACKGROUND Crocin is an active ingredient of saffron (Crocus sativus L.) and its antioxidant properties have been previously investigated. This carotenoid scavenges free radicals and stimulates glutathione (GSH) synthesis; consequently, it may protect cells against oxidative stress. The aim of this research is to protect oocytes from oxidative stress by the addition of a natural source antioxid...

OBJECTIVE Crocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. MATERIALS AND METHODS Subcutaneous injection of a diluted formal...

This study was designed to investigate the therapeutic effects of saffron (Crocus Sativus L) and its main constituent crocin on neuropathic pain behavioral responses induced by chronic constriction injury (CCI) in rats. Adult male Wistar rats (200 to 250 g) were randomly assigned into 5 groups: Sham + saline, CCI + saline, CCI+ saffron (30 mg/kg), CCI +crocin (15 mg/kg) and CCI + crocin (30 mg/...

OBJECTIVES In this study the effect of crocin, a carotenoid isolated from saffron, on malathion (an organophosphate insecticide) induced depressive- like behavior in subacute exposure was investigated. Moreover the molecular mechanism of malathion induced depressive- like behavior and its decreasing effect on the level of brain derived neurotrophic factor (BDNF) in rat hippocampus and cerebral ...

objective(s):alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. one of the hallmarks of ad is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. in this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in ad and tauopathies. unfortunately, the available syn...