this study presented a mini review on folic acid deficiency and recommendations for its supplementation in thalassemia intermedia (ti). ti is a clinical condition which lies between thalassemia major and thalassemia minor. although ti patients may not need regular blood transfusion, precise diagnosis and management are critical for the prevention of clinical complications and quality of life im...

B lymphopoiesis in bone marrow (BM) is critical for maintaining a diverse peripheral B cell pool to fight infection and establish lifelong immunity. The generation of immature B cells is reduced in Flt3-ligand (FL-/-) mice leading to deficiencies in splenic B cells. Here, we sought to understand the cellular basis of the spleen B cell deficiency in FL-/- mice. Significant reductions in transiti...

tent, on the other hand, have the potential to attenuate phytotoxic B concentrations (Goldberg, 1993). Detailed Soil texture often varies dramatically in both vertical and horizontal quantification of B adsorption reactions is necessary to directions in field situations and affects the amount of B adsorbed and B movement. This study was conducted to evaluate the effect of understand the fate an...

Wild-type p53-induced phosphatase 1 (Wip1), a phosphatase previously considered as an oncogene, has been implicated in the regulation of thymus homeostasis and neutrophil maturation. However, the role of Wip1 in B-cell development is unknown. We show that Wip1-deficient mice exhibit a significant reduction of B-cell numbers in the bone marrow, peripheral blood, and spleen. A reciprocal transpla...

The immunological synapse (IS), a dynamic and organized junction between T-cells and antigen presenting cells (APCs), is critical for initiating adaptive immunity. The actin cytoskeleton plays a major role in T-cell reorganization during IS formation, and we previously reported that transgelin-2, an actin-binding protein expressed in T-cells, stabilizes cortical F-actin, promoting T-cell activa...

Paradoxical observations have been made regarding the role of caveolin-1 (Cav-1) during cellular senescence. For example, caveolin-1 deficiency prevents reactive oxygen species-induced cellular senescence despite mitochondrial dysfunction, which leads to senescence. To resolve this paradox, we re-addressed the role of caveolin-1 in cellular senescence in human diploid fibroblasts, A549, HCT116,...

Boron (B) is a micronutrient indispensable for citrus and B deficiency causes a considerable loss of productivity and quality in China. However, studies on pectin composition and architecture of cell wall components in trifoliate orange roots under B deficiency condition are not sufficient. In this study, we investigated the alteration in pectin characteristics and the architecture of cell wall...

A critical characteristic of iron nutrition in infancy, as compared to adults, is the greater dependency of the infant on external sources of iron for daily red cell production. Dallman et al. (1) have calculated that in a 1-year-old, 10-kg infant, dietary iron must provide 30% of the needs for hemoglobin iron turnover as compared to only 5% in the adult male (Table 1). This imposes disproporti...

marshmallow is a medicinal plant containing mucilage polysaccharides and various phenolic acids. boron (b) is an essential micronutrient whose necessity for plant growth and development has been attributed to its role in cell wall pectin network and maintenance of integrity and performance of membranes. the present study was aimed to investigate the effects of different concentrations of b (0.0...