To determine the roles of mutation, migration, and selection in maintaining genetic variability in populations of house mice (Mus musculus), stochastic models based on characteristics of mouse populations inhabiting corn cribs in southwestern Ontario and the t allele were developed. Two sets of models were examined. One involved selection against t/t mice and a migration rate of 0.05 to 0.10 (l...

The purpose of this paper is to investigate the fire performance in a multi-storey cross-laminated timber (CLT) structure by computational fluid dynamics (CFD) technique using Fire Dynamics Simulator (FDS v.6.7). study investigates temperature, heat release rate (HRR), and gas concentration (O2, CO2). importance research ensure that buildings adequate for occupant safety property protection. Mo...

within a stage that reproduces a disrupted natural order: incubators, parenteral feeding, mechanical lactation; technology as a necessary but grotesque surrogate. The father, standing in the halls or undaunted, close to his children, swallows the anguish or escapes from reality in a sort of dignified manner. But fathers, in that barren nowhere awaiting for luck or calamity, is also aware. Many ...

BACKGROUND The purpose of this study was to review state regulations promoting increased physical activity and decreased sedentary behaviors in infants in child care and to assess consistency with recent Institute of Medicine (IOM) recommendations. METHODS We compared existing state and territory licensing and administrative regulations to recent IOM recommendations to promote physical activi...

Objective: The aim of present study was to carry out a retrospective analysis types and causes ENT injuries in pediatric age group. Patients Methods: We carried 40 children up the 14 years with managed department period from March 2019 April 2021. Results: total number patients it comprised 31 males (77.5%) 9 females (22.5%). Twelve (30%) were under 5 years, 14(35%) 6-10 (35%) group 11–14 yea...

Mutagenesis was used to probe the interface between the small GTPase Cdc42p and the CRIB domain motif of Ste20p. Members of a cluster of hydrophobic residues of Cdc42p were changed to alanine and/or arginine. The interaction of the wild-type and mutant proteins was measured using the two-hybrid assay; many, but not all, changes reduced interaction between Cdc42p and the target CRIB domain. Muta...

AIMS To assess whether changes in survival over time in infants of 23 to 25 weeks of gestational age were accompanied by changes in the incidence of disability in childhood during an 11 year period. METHODS Obstetric and neonatal variables having the strongest association with both survival to discharge from a regional neonatal medical unit and neurodevelopmental disability in 192 infants of ...

We have identified a new Dictyostelium p21-activated protein kinase, PAKc, that we demonstrate to be required for proper chemotaxis. PAKc contains a Rac-GTPase binding (CRIB) and autoinhibitory domain, a PAK-related kinase domain, an N-terminal phosphatidylinositol binding domain, and a C-terminal extension related to the Gbetagamma binding domain of Saccharomyces cerevisiae Ste20, the latter t...

Strontium-90 is a major hazardous contaminant of radioactive wastewater and its processing sludges at many Department of Energy (DOE) facilities. In the past, such contaminated wastewater and sludge have been disposed in soil seepage pits, lagoons, or cribs often under highly perturbed alkaline conditions (pH > 12) where 90Sr solubility is low and its adsorption to surrounding soil is high. As ...