Wood cribs pervade the fire research literature as chosen fuel load for testing within built environment. As such, underpinning knowledge of behaviour in compartments was developed from experiments using wood small compartments. Despite apparent incomparability porous fuel-beds such to real solid fuels environment, role mass transfer number (“B-Number”) defining compartment dynamics has receive...

AIMS To assess whether changes in survival over time in infants of 23 to 25 weeks of gestational age were accompanied by changes in the incidence of disability in childhood during an 11 year period. METHODS Obstetric and neonatal variables having the strongest association with both survival to discharge from a regional neonatal medical unit and neurodevelopmental disability in 192 infants of ...

BACKGROUND Impoverishment and crowding are associated with an increased risk of sudden unexpected death among infants. Bed sharing likely increases this risk, particularly among African American infants. OBJECTIVES To compare the sleep environment of African American infants who bed share with that of infants who do not share sleep surfaces and to compare access to a safe crib, and the space ...

OBJECTIVE The goal was to assess the feasibility of earlier weaning from the incubator for preterm infants. METHODS This was a prospective, randomized study with preterm infants with birth weights of <1600 g who were admitted to a neonatal subintensive ward. Findings for 47 infants who were transferred from an incubator to an open crib at >1600 g (early transition group) were compared with th...

BACKGROUND The Rho GTPases Rho, Rac, and Cdc42 regulate the organization of the actin cytoskeleton by interacting with multiple, distinct downstream effector proteins. Cdc42 controls the formation of actin bundle-containing filopodia at the cellular periphery. The molecular mechanism for this remains as yet unclear. RESULTS We report here that Cdc42 interacts with IRSp53/BAP2 alpha, an SH3 do...

AIM To determine the perinatal factors associated with initial illness severity (measured by the CRIB (clinical risk index for babies) score) and its relation to survival to discharge. METHODS A retrospective study was made of intensive care nursing records on 380 inborn babies, of less than 31 weeks gestation or 1501 g birthweight, admitted to one unit between 1984-6 and 1991-4. RESULTS Be...

family of CRIB domain–containing proteins is represented by the nonreceptor tyrosine kinases ACK-1 (Manser et al., 1993) and ACK-2 (Yang et al., 1997), which are highly specific targets for Cdc42. While these tyrosine kinases have yet to be linked to a specific pathological condition, it is likely that they will play important roles in neuronal cell function as they are highly expressed in brai...

AIM To compare the survival of premature infants, adjusted for disease severity, in different types of neonatal intensive care setting. METHODS A prospective observational study in the Trent Health Region was carried out of all infants born to resident mothers at or before 32 weeks of gestation between 1 January 1994 to 31 December 1996 inclusive. The 16 neonatal units in Trent were subdivide...