Assessing the initial severity of immunoglobulin A vasculitis nephritis (IgAV-N) is important due to its determining effect on kidney management and outcomes. This paper describes a multicentre paediatric cohort IgAV-N patients discusses relationships among clinical presentation, histological features, outcome. We retrospectively studied 170 children with biopsy-proven IgAV-N, diagnosed between...

We employed a novel technique to inspect the substrate-apposed surface of activated osteoclasts, the cells that resorb bone, in the scanning electron microscope. The surface revealed unexpected complexity. At the periphery of the cells were circles and crescents of individual or confluent nodules. These corresponded to the podosomes and actin rings that form a 'sealing zone', encircling the res...

BACKGROUND The associations of glomerular capillary and endothelial injury with the formation of necrotizing and crescentic lesions in cases of crescentic glomerulonephritis (GN) have not been evaluated in detail. METHODS Glomerular capillary and endothelial cell injury were assessed in renal biopsy specimens of crescentic GN, including those from patients with anti-neutrophil cytoplasmic aut...

Abstract Background The prognostic value and response to immunosuppressive therapy (IST) of patients with crescents in the different backgrounds pathological presentations IgA nephropathy (IgAN) is unclear. Methods 1262 IgAN were enrolled. Crescents (C, 0/1/2), fibrinoid necrosis (FN, 0/1) endocapillary hypercellularity (E, integrated into degrees glomerular activity (0–4 points): mild (0), mod...

Symbolic religious establishment (SRE), that is, the noncoercive recognition of religion by state, has become object a growing debate in political philosophy. Although SRE is purely symbolic, some have argued it can be wrong because message inequality sends. The indeterminacy this expressive argument makes its application problematic, however. objective article to improve applicability expressi...

Background: IgA nephropathy was a syndrome of uniform morphology, diverse clinical features and uncertain prognosis, presence of crescents around blood vessels indices the unfavorable long-term prognosis, if the proportion of crescent in glomeruli exceeding ratio of 50%, we give the active treatment of prednisone pulse therapy, but in most condition, IgA nephropathy was diagnosed with a few of ...