Serum creatinine is commonly used as a marker of renal function, but increases in serum creatininemight not represent changes in glomerular filtration rate (GFR). INCB039110 (2-(3-(4-(7H-pyrrolo[2,3-day]pyrimidin4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl) piperidin-4-yl)azetidin-3-yl)acetonitrile) is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1....

Serum creatinine is commonly used as a marker of renal function, but increases in serum creatininemight not represent changes in glomerular filtration rate (GFR). INCB039110 (2-(3-(4-(7H-pyrrolo[2,3-day]pyrimidin4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl) piperidin-4-yl)azetidin-3-yl)acetonitrile) is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1....

background because of difficulty in obtaining a 24-hour urine collection in children, a random sample of urine is often used to calculate the urinary calcium to creatinine ratio. urinary calcium excretion might be influenced by genetic, geographic area, etc. in this study, the value of urinary calcium, creatinine, sodium and potassium excretion and age–related reference values for urine calcium...

conclusions the major finding of this study is that one unit increase in serum creatinine level suggests an increased risk of graft failure of up to four times. patients and methods this study was carried out at the department of nephrology, baqiyatallah hospital, baqiyatallah university, tehran, iran, between april 2005 and december 2008. during that time period, 461 patients who had undergone...

Glomerular filtration rate (GFR) is commonly assessed by measurement of endogenous creatinine clearance (Ccr). Several formulae have been described to calculate Ccr from plasma creatinine. I have evaluated the effectiveness of four formulae in 35 healthy subjects (21M and 14F, 18-34 years) and in 41 patients (24M, 17F, 20-69 years) attending a renal clinic with diminished renal function (serum ...

OBJECTIVES This study aimed to evaluate any correlations between baseline creatinine clearance and the development of grade 3/4 toxicities during treatment within oncology phase I trials of molecularly targeted agents where entry criteria mandate a serum creatinine of ≤ 1.5 × the upper limit of normal. METHODS Documented toxicity and creatinine clearance (calculated by the Cockcroft-Gault for...

Albuminuria is the most characteristic marker of diabetic nephropathy (DN), which a complication associated with DN progression. However, renal functions decreased by about one-third patients before occurrence albuminuria. We study role telomere length (TL) blood leukocytes, some inflammatory markers in progression type 1 diabetes (T1D). Volunteers were selected and distributed into four groups...