Apart of its well known function of “energetic buffer” through the creatine / phosphocreatine / creatine kinase system allowing the regeneration of ATP, creatine has been recently suggested as a potential neuromodulator of even true neurotransmitter. Moreover, the recent discovery of primary creatine deficiency syndromes, due to deficiencies in AGAT or GAMT (the two enzymes allowing creatine sy...

An organism able to grow in a simple medium with creatine as the main C and N source was isolated from garden soil and subsequently identified as Pseudomonas ovalis Chester. Organisms harvested from a creatine-containing medium destroyed creatine with the uptake of 0, and the forination of CO,, NH, and urea. With the exception of urea the quantities of reactants fell short of those required by ...

Deficiency of guanidinoacetate N-methyltransferase (GAMT) is the first described creatine (CT) deficiency syndrome in man, biochemically characterized by accumulation of guanidinoacetic acid (GAA) and depletion of CT. Patients exhibit severe developmental and muscular problems. We created a mouse model for GAMT deficiency, which exerts biochemical changes comparable with those found in human GA...

Background Given the relationship of vitamin D deficiency with insulin resistance syndrome as the component of polycystic ovary syndrome (PCOS), the main aim of this study was to compare serum level of 25- hydroxyvitamin D [25(OH)D] between PCOS patients and normal individuals. MaterialsAndMethods A cross sectional study was conducted to compare 25(OH)D level between117 normal and 125 untreated...

leukocyte adhesion deficiency type 1 (lad 1) is an autosomal recessive hereditary disorder resulting from deficiency of cd18, characterized by recurrent bacterial infections. we report two consanguineous patients with leukocyte adhesion deficiency type 1( lad1). these two infant boy patients were referred to us, within a short period of time, with the complaints of recurrent infections at the a...

Most athletes use food supplements to obtain a well-trained, athletic, and healthy looking body. Supplementation practices vary between sports and individual athletes. Many athletes take food additives, containing vitamin E and food additives with creatine because of their favorable effects on muscle mass. Vitamin E deficiency leads to serious damage to the body, especially the muscles. Antioxi...

Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated similar to neurotransmitters, creatine released in an excitotoxic action potential-dependent manner acts as neuromodulator. deficiency syndromes are characterized by severe mental developmental disorders. Studies have reported brain content could be enhanced ...