Cyclophosphamide (CP) is one of the anti-neoplastic drugs. Despite its numerous clinical applications, it has devastating effects on the testicles and declines the sperm quality in treated patients. This study was aimed to investigate the protective effect of crocin in improving the toxicity induced by CP in reproductive system. In this study, 24 male adult mice (6 to 8 weeks) were randomly div...

Density functional theory (DFT) calculations were performed on tripeptide arginyl-glycyl-aspartic acid (RGD) as an efficient drug carrier to deliver the commercially famous cyclophosphamide (CP) anticancer drug within ethanol solution. The most negative binding energy (-5.22 kcal/mol) was measured for the CP-RGD-7 created through the H-bond interaction between the P=O (phosphoryl) oxygen atom o...

breast cancer is the most common cancer in women worldwide. breast cancer in one third of all patients will go on to metastasis, which is the main cause of mortality in cancer cases. tumor cells detach from primary tumor and enter into the circulation as circulating tumor cells (ctcs) which can form metastatic lesions. in this study, the expression of ck-19 gene in blood samples of metastatic b...

Objective: Diabetes mellitus is a metabolic disorder associated with impaired serum skeletal muscle pain enzymes levels. The purpose of this study was to investigate the effect of 8 weeks aerobic training with and without vitamin C consumption on serum levels of Creatine Kinase (CK) in type 2 diabetic patients (T2DM). Materials and Methods: In this clinical trial 45 women (30-45 years) with T2...

Abstract On the morning of 6 May 2021, military police invaded favela Jacarezinho, one Rio de Janeiro's slums, and killed 28 people during a operation tellingly named Operation Exceptis. Photos dead bodies in alleys denouncements extrajudicial executions individuals who had already surrendered circulated widely on internet. Jacarezinho adds to troubling record killings that includes goes far be...