1 NESFATIN-1: MELANOCORTINS, CORTICOTROPIN RELEASING HORMONE AND 2 OXYTOCIN 3 4 5 6 Gina L. C. Yosten and Willis K. Samson 7 8 Department of Pharmacological and Physiological Science 9 Saint Louis University School of Medicine 10 Saint Louis, Missouri 11 12 13 14 Running Title: Neural Circuitry of Nesfatin-1 15 16 17 18 19 20 Corresponding Author: 21 22 Gina L. C. Yosten, Ph.D. 23 24 Department...

We studied glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressed patients and controls, attempting to control for the confounding effect of endogenous glucocorticoids. After depletion of endogenous cortisol, depressed patients showed an attenuated suppressibility of corticotropin by dexamethasone in the face of unchanged dexamethasone plasma levels. Bet...

The present study is designed to elucidate the involvement of neuronal mechanisms in corticotropin-releasing factor (CRF)-induced anti-oedema effects. Oedema was induced in the rat hind paw by subcutaneous injection of 3 nmol of serotonin (5-HT). A single dose of CRF (9.4, 37.5 or 75 pmol) was given either ipsilaterally or contralaterally 30 min before 5-HT injection and oedema formation was su...

Robust physiological actions of the neuropeptide corticotropin-releasing hormone (CRH) on hippocampal pyramidal neurons have been demonstrated, which may contribute to synaptic efficacy and to learning and memory processes. These excitatory actions of the peptide, as well as the expression of the CRH receptor type that mediates them, are particularly prominent during early postnatal life, sugge...

We have previously hypothesized that corticotropin-releasing hormone (CRH) is involved in the regulation of physiological waking. To further elucidate this role for CRH, we administered intracerebroventricularly into rats two specific CRH-receptor antagonists, α-helical CRH-(9-41) (α-hCRH) or astressin, and determined changes in electroencephalogram-defined waking and sleep. Our results indicat...

The corticotropin-induced increase of total intracellular and receptor-bound cyclic AMP in isolated rat adrenocortical cells was strictly dependent on extracellular Ca(2+). A rise in bound cyclic AMP with rising Ca(2+) concentrations was accompanied by a decrease in free cyclic AMP-receptor sites. A Ca(2+)-transport inhibitor abolished the rise in bound cyclic AMP induced by corticotropin. Thes...

Understanding the many roles that corticotropin-releasing hormone (CRH) plays in facilitating the ordinary and extraordinary events that an individual faces during a lifetime is a complex task, and yet this knowledge is fundamental to understanding our own behaviour and physiology. During the past 25 years, the study of CRH in nonhuman primates, our closest genetic relatives, has grown rapidly....

Environmentally induced phenotypic plasticity allows developing organisms to respond adaptively to changes in their habitat. Desert amphibians have evolved traits which allow successful development in unpredictable environments. Tadpoles of these species can accelerate metamorphosis as their pond dries, thus escaping mortality in the larval habitat. This developmental response can be replicated...