UNLABELLED Noninvasive brain stimulation studies have shown abnormal motor cortical plasticity in Parkinson's disease (PD). These studies used peripheral nerve stimulation paired with transcranial magnetic stimulation (TMS) to primary motor cortex (M1) at specific intervals to induce plasticity. Induction of cortical plasticity through stimulation of the basal ganglia (BG)-M1 connections has no...

Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response--100 μA), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distri...

Noninvasive cortical stimulation (NICS) can produce analgesic effects by means of repetitive transcranial magnetic stimulation or transcranial direct current stimulation (tDCS). Such effects have been demonstrated on chronic ongoing pain, as in acute provoked pain. The investigation of induced changes in the perception of experimental pain by NICS could help clinicians and researchers to better...

objectives: this study sought to assess the relation of mandibular cortical index (mci) with age, gender and gonial angle size in an iranian adult population using digital panoramic radiography. methods: we evaluated 370 digital panoramic radiographs of patients and divided them into five 10-year age groups. each radiograph was assigned to low (≤120°) or high (≥125°) angle groups in terms of th...

Brief-pulse stimulation at 50 Hz has been shown to terminate afterdischarges observed in epilepsy patients. However, the optimal pulse stimulation parameters for terminating cortical electrical stimulation-induced afterdischarges remain unclear. In the present study, we examined the effects of different brief-pulse stimulation frequencies (5, 50 and 100 Hz) on cortical electrical stimulation-in...

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Transcranial magnetic stimulation (TMS) is a safe and noninvasive tool for investigating the cortical excitability of human brain neurophysiological functions GABAergic, glutamatergic, cholinergic neural circuits. Neurophysiological biomarkers based on TMS parameters can provide information pathophysiology dementia, be used to diagnose Alzheimer’s disease differentiate different types dementi...

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This paper is a review of physiological and behavioral data on motor cortex stimulation (MCS) and its role in persistent neuropathic pain. MCS has been widely used in clinical medicine as a tool for the management of pain that does not respond satisfactorily to any kind of conventional analgesia. Some important mechanisms involved in nociceptive modulation still remains unclear. The aim of this...