Corneal keratoplasty (penetrating or lamellar) using cadaveric human tissue, is nowadays the main treatment for corneal endotelial dysfunctions. However, there is a worldwide shortage of donor corneas available for transplantation and about 53% of the world's population have no access to corneal transplantation. Generating a complete cornea by tissue engineering is still a tough goal, but an en...

Purpose: To report a case with corneal ulcer after keratoplasty connected to long-term use of topical 0.1% diclofenac sodium. Methods: A 81-year-old man presented with corneal ulceration. The patient’s clinical history showed that he had keratoplasy after ocular trauma for about 10 years ago. He was using topical dexamethasone sodium phosphate 0.1% and topical diclofenac sodium 0.1% for one yea...

Corneal transplantation is the most common form of organ transplantation performed globally. However, of all organs, eyes have the highest rate of refusal of donation. This study explored the reasons why individuals decide whether or not to donate corneas. Twenty-one individuals were interviewed who had made a donation decision (13 refused corneal donation and eight consented). Analysis was per...

BACKGROUND Indications for corneal transplantation in developed and developing nations differ according to the different spectrum of corneal disease in each country. OBJECTIVE The purpose of this study is to analyze the changing indications and surgical techniques for corneal transplantation over the past 20 years at a tertiary referral center in Turkey. METHODS We retrospectively reviewed ...

PURPOSE To summarize the current concepts and recent literature regarding the epidemiology, pathogenesis, imaging modalities, and treatment of acute hydrops in keratoconus. DESIGN Perspective. METHODS Review and synthesis of selected literature, with interpretation and perspective. RESULTS Acute corneal hydrops is an incompletely understood complication of keratoconus, characterized by ma...

PURPOSE To analyze whether tyrosine kinase inhibitors blocking VEGF receptors (PTK787/ZK222584 [PTK/ZK] and ZK261991 [ZK991]) can inhibit not only hemangiogenesis but also lymphangiogenesis and whether treatment with tyrosine kinase inhibitors after corneal transplantation can improve graft survival. METHODS Inflammatory corneal neovascularization was induced by corneal suture placement. One ...